TAILIEUCHUNG - Báo cáo y học: "Efficacy and long-term follow-up of IL-1R inhibitor anakinra in adults with Still’s disease: a case-series study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Efficacy and long-term follow-up of IL-1R inhibitor anakinra in adults with Still’s disease: a case-series study. | Laskari et al. Arthritis Research Therapy 2011 13 R91 http content 13 3 R91 RESEARCH ARTICLE Open Access Efficacy and long-term follow-up of IL-1R inhibitor anakinra in adults with Still s disease a case-series study Katerina Laskari Athanasios G Tzioufas and Haralampos M Moutsopoulos Abstract Introduction To assess the efficacy and safety of the interleukin-1 receptor IL-1R inhibitor anakinra in adult patients with refractory Still s disease. Methods Twenty-five patients 13 males and 12 females median age 32 years median disease duration seven months with Still s disease were treated with subcutaneous injections of anakinra 100 mg day . Treatment was given as adjunct therapy in 16 patients and as standalone in 9 patients for a median time of 15 months range . The clinical and laboratory parameters during follow-up were recorded. Results In 84 of patients the clinical activity resolved completely within a few days median time months and response was maintained until the last visit in all but one patient. A complete response of all disease-related symptoms clinical and laboratory occurred subsequently within a median time of three months in 80 of patients. A partial clinical and laboratory improvement was shown in 12 and 16 of patients respectively. The Visualized Analogue Scale and Health Assessment Questionnaire scores significantly decreased during treatment. The proportion of patients achieving the American College of Rheumatology 20 ACR20 score 20 improvement was 82 at one month and improved to 100 at one year. The mean oral corticosteroid dose was significantly reduced at each visit. Anakinra was discontinued due to unresponsiveness in one patient and due to relapsing disease in another. Treatment was also withdrawn in three patients with severe skin reactions urticaria . Seven patients experienced an infection during follow-up. Conclusions The rapid and sustained response in the majority of our patients encourages the use of

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