TAILIEUCHUNG - Báo cáo y học: "The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis. | Available online http content 8 6 R187 Research article The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases matrix metalloproteinases and other destructive and inflammatory responses in osteoarthritis Jan Bondeson1 Shane D Wainwright2 Sarah Lauder1 Nick Amos1 and Clare E Hughes2 Department of Rheumatology Cardiff University Heath Park Cardiff CF14 4XN UK 2Connective Tissue Biology Laboratories Cardiff School of Biosciences Cardiff University Museum Avenue Cardiff CF10 3US UK Corresponding author Jan Bondeson BondesonJ@ Received 30 May 2006 Revisions requested 31 Jul 2006 Revisions received 10 Nov 2006 Accepted 19 Dec 2006 Published 19 Dec 2006 Arthritis Research Therapy 2006 8 R187 doi ar2099 This article is online at http content 8 6 R187 2006 Bondeson et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract There is an increasing body of evidence that synovitis plays a role in the progression of osteoarthritis and that overproduction of cytokines and growth factors from the inflamed synovium can influence the production of degradative enzymes and the destruction of cartilage. In this study we investigate the role of synovial macrophages and their main proinflammatory cytokines interleukin IL -1 and tumour necrosis factor-alpha TNF-a in driving osteoarthritis synovitis and influencing the production of other pro- and anti-inflammatory cytokines production of matrix metalloproteinases and expression of aggrecanases in the osteoarthritis synovium. We established a model of cultures of synovial cells from digested osteoarthritis synovium derived from patients undergoing knee or hip arthroplasties. By means .

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