TAILIEUCHUNG - Báo cáo y học: "Boswellic acids extract attenuates pulmonary fibrosis induced by bleomycin and oxidative stress from gamma irradiation in rats"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Boswellic acids extract attenuates pulmonary fibrosis induced by bleomycin and oxidative stress from gamma irradiation in rats. | Ali and Mansour Chinese Medicine 2011 6 36 http content 6 1 36 CHINESE MEDICINE RESEARCH Open Access Boswellic acids extract attenuates pulmonary fibrosis induced by bleomycin and oxidative stress from gamma irradiation in rats Eman Noaman Ali and Somaya Zakaria Mansour Abstract Background Interstitial pulmonary fibrosis is characterized by an altered cellular composition of the alveolar region with excessive deposition of collagen. Lung inflammation is also common in pulmonary fibrosis. This study aims to test the inhibition of 5-lipooxygenase 5-LOX by boswellic acid BA extract in an experimental model of pulmonary fibrosis using bleomycin BL . Methods Boswellic acid extract 1 g kg was force-fed to rats seven days prior to administration of BL or gamma irradiation or both. BL U rat in 25 pl of normal saline NS or NS alone was administered intratracheally. Rats were exposed to two fractionated doses of gamma irradiation Gy dose week with a gamma cell-40 Cesium-137 irradiation units Canada during the last two weeks of the experiment. BA was administered during BL or irradiation treatment or both. After the animals were sacrificed bronchoalveolar lavage was performed lungs were weighed and processed separately for biochemical and histological studies. Results In rats treated with BL levels of transforming growth factor-p1 TGF P1 and tumor necrosis factor-a TNF-a were significantly elevated P and P . Hydroxyproline was highly and extensively expressed. Immunoreactive compounds were abundantly expressed represented in the levels of macrophages infiltrate accumulation of eosinophils and neutrophils in the lung as well as the aggregation of fibroblasts in the fibrotic area. The levels of lipoxygenase enzyme activity were significantly increased P . Antioxidant activities measured in BL-treated rats deteriorated coupled with the elevation of both levels of plasma lipid peroxide LP content and bronchoalveolar lavage .

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