TAILIEUCHUNG - Two faces of the coin: Minireview for dissecting the role of reactive oxygen species in stem cell potency and lineage commitment

Reactive oxygen species (ROS) are produced as by-products of several intracellular metabolic pathways and are reduced to more stable molecules by several protective pathways. The presence of high levels of ROS can be associated with disturbance of cell function and could lead to apoptosis. The presence of ROS within the physiological range has many effects on several signalling pathways. In stem cells, this role can range between keeping the potency of the naive stem cells to differentiation towards a certain lineage. In addition, the level of certain ROS would change according to the differentiation stage. For example, the presence of ROS can be associated with increasing the proliferation of mesenchymal stem cells, decreasing the potency of embryonic stem cells and adding to the genomic stability of induced pluripotent stem cells. ROS can enhance the differentiation of stem cells into cardiomyocytes, adipocytes, endothelial cells, keratinocytes and neurons. In the meantime, ROS inhibits osteogenesis and enhances the differentiation of cartilage to the hypertrophic stage, which is associated with chondrocyte death. Thus, ROS may form a link between naïve stem cells in the body and the environment. In addition, monitoring of ROS levels in vitro may help in tissue regeneration studies. | Two faces of the coin: Minireview for dissecting the role of reactive oxygen species in stem cell potency and lineage commitment

• Hoá học
• Stem cells
• Reactive oxygen species
• Dissecting the role
• Reactive oxygen species
• Stem cell potency
• Lineage commitment
• Phenotypic of expanded adipose derived stem cells
• Cytogenetic characterization of expanded adipose derived stem cells
• Expanded adipose derived stem cells
• Adipose stem cells
• Human adipose derived stem cells
• Cancer stem cells
• Precancerous stem cells
• Very small embryonic like stem cells
• Pharmacological strategies
• Drug resistance
• Regenerative medicine
• Stem cells and regenerative medicine
• Stem cells for the nervous system
• Nervous system
• Stem cells for liver
• Embryonic stem cells
• Induced pluripotent stem cells
• Mesenchymal stem cells
• Stem cell based therapy
• Human embryonic stem cell
• Primordial germ cells
• Genetic reprogramming
• Transcription factors
• Embryonic germ cells
• Nuclear reprogramming
• Stem cell fate
• Leukemic stem cells
• Treatment of tumors
• Heterogeneous cell
• Leukemia elegantly
• Bone regeneration
• Dental pulp stem cells
• Human periapical cysts mesenchymal stem cells
• hPCy MSCs
• Inhibited growth of mesenchymal stem cells
• Mesenchymal stem cells under simulated microgravity
• Simulated microgravity
• Cyclin dependent kinase 6
• Transfection efficiency
• Pluronic PF68
• Transfect human tooth germ stem cells
• BMC Cancer
• Type 35 adenovirus fiber
• Human mesenchymal stem cells
• Coxsackie adenovirus receptor
• Limbal stem cell deficiency
• Limbal epithelial transplantation
• Limbal stem cells
• Stem cell transplantation
• Cell tracking
• BMC Pediatrics
• Hematopoietic stem cells
• Peripheral blood circulating stem cells
• Blood testing
• Premature infants
• Cell reprogramming
• Dental pulp
• Definitive endoderm
• Cryopreserved dental pulp tissues
• Hepatocyte like cells
• Endothelial cells from porcine induced pluripotent stem cells
• Optimized single layer culture system
• Porcine induced pluripotent stem
• CD31 positive cells
• Low density lipoprotein
• Adipose tissue
• Wound healing
• Multipotent character
• Three dimensional cell culture
• Umbilical cord mensenchymal stem cells
• Hepatocellular carcinoma
• Glioma stem cell
• Mesenchymal stem cell
• Cell fusion
• Glioma neovascularization
• Testes somatic stem cells
• JAK/STAT signaling
• Genetically tractable
• Stem cell biology
• Therapeutic cells
• Clinical trials
• Therapeutic cells to pretrial clinical research
• Japanese brand sources
• Journal of Biology
• Endothelial cells
• Fluid shear stress
• Integrin β1
• Human umbilical vein endothelial cells (HUVECs)
• Oxidative stress
• Antioxidant enzymes
• Cardiomyogenic differentiation
• Plasma gel
• Tissue engineering
• Pelizaeus–Merzbacher disease
• Multiple sclerosis
• Subacute sclerosing panencephalitis