TAILIEUCHUNG - Ethical and safety issues of stem cell based therapy

Results obtained from completed and on-going clinical studies indicate huge therapeutic potential of stem cell-based therapy in the treatment of degenerative, autoimmune and genetic disorders. However, clinical application of stem cells raises numerous ethical and safety concerns. | 36 Int. J. Med. Sci. 2018 Vol. 15 ivyspring international publisher Review InternationalJournal ofMedicalSciences 2018 15 1 36-45. doi Ethical and Safety Issues of Stem Cell-Based Therapy Vladislav Volarevic1 Bojana Simovic Markovic1 Marina Gazdic2 Ana Volarevic1 Nemanja Jovicic3 Nebojsa Arsenijevic1 Lyle Armstrong4 Valentin Djonov5 Majlinda Lako4 and Miodrag Stojkovic2 1. University of Kragujevac Serbia Faculty of Medical Sciences Department of Microbiology and Immunology Center for Molecular Medicine and Stem Cell Research 2. University of Kragujevac Serbia Faculty of Medical Sciences Department of Genetics 3. University of Kragujevac Serbia Faculty of Medical Sciences Department of Histology and Embryology 4. Institute of Genetic Medicine Newcastle University UK 5. Institute of Anatomy University of Bern Bern Switzerland. Corresponding author Prof. Vladislav Volarevic Department of Microbiology and Immunology Center for Molecular Medicine and Stem Cell Research Faculty of Medical Sciences University of Kragujevac 69 Svetozar Markovic Street 34000 Kragujevac Serbia. Phone 38134306800 fax 38134306800 ext. 112. E-mail drvolarevic@ Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution CC BY-NC license https licenses by-nc . See http terms for full terms and conditions. Received Accepted Published Abstract Results obtained from completed and on-going clinical studies indicate huge therapeutic potential of stem cell-based therapy in the treatment of degenerative autoimmune and genetic disorders. However clinical application of stem cells raises numerous ethical and safety concerns. In this review we provide an overview of the most important ethical issues in stem cell therapy as a contribution to the controversial debate about their clinical usage in regenerative and transplantation medicine. We

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• Embryonic stem cells
• Induced pluripotent stem cells
• Mesenchymal stem cells
• Stem cell based therapy
• Human embryonic stem cell
• Primordial germ cells
• Stem cells
• Genetic reprogramming
• Transcription factors
• Embryonic germ cells
• Cancer stem cells
• Precancerous stem cells
• Very small embryonic like stem cells
• Pharmacological strategies
• Drug resistance
• Regenerative medicine
• Stem cells and regenerative medicine
• Nuclear reprogramming
• Stem cell fate
• BMC Molecular and Cell Biology
• Extracellular matrix
• Self renewal
• Self renewal capacity
• Multiple stem cell markers
• Genome Biology
• Single cell RNA seq
• Definitive endoderm
• Wave Crest
• Human pluripotent
• Stem cells into progenitor
• BMC Pediatrics
• Hematopoietic stem cells
• Peripheral blood circulating stem cells
• Blood testing
• Premature infants
• BMC Biotechnology
• Goat embryonic fibroblasts
• Goat iPS cells
• mRNA induced iPSCs formation
• Cell reprogramming
• Human embryonic stem cell N glycans
• N glycan core branching
• Human induced pluripotent stem cells
• Glycan binding proteins
• Dental pulp
• Cryopreserved dental pulp tissues
• Hepatocyte like cells
• Tạp chí khoa học
• Tạp chí sinh học
• Bovine embryonic stem cells
• Leukemia inhibitory factor
• Pluripotent genes
• Embryonic stem cell
• Sex conversion
• Germ cells
• Functional germ cells
• Chimeric mice produced
• BMC Cancer
• Human embryonic stem cells
• Familial adenomatous polyposis
• Adenomatous polyposis coli
• aPC gene
• Cyclin dependent kinases
• Apoptotic stimuli
• Cell based therapeutic purposes
• X chromosome
• Gene dosage
• Sex differences
• MAPK signaling
• H3K27 acetylation
• Gene transcription
• Enhancer activity
• Mouse embryonic stem cells
• Distal regulators
• Gene expression
• Complex network of enhancers
• Intracisternal A particles
• Ten eleven translocation enzymes
• DNA methylation
• Histone arginine methylation
• Human genomes
• Ten eleven translocation enzymes
• RNA methylation
• 5 Methylcytosine
• Mouse brain
• RNA binding proteins
• Bisulfite sequencing
• Heritable epigenetic mark
• Modifying cytosine
• Turkish Journal of Biology
• Morphological analysis
• Alkaline phosphatase staining
• Ebook Chemical
• Functional genomic approaches
• Stem cell biology
• Adult stem cells
• Cell fusion
• Hepatocellular carcinoma
• Stem cell
• Tumor initiating cell