TAILIEUCHUNG - A letter in response to “Cancer stem cells: Emerging actors in both basic and clinical cancer research” Cancer stem cells (CSCs): targets and strategies for intervention

This letter to the editor highlights the important aspects of cancer stem cells and provides a deeper insight into the origin and characterization of these cells as well as the mechanisms contributing to drug resistance and relapse. The two currently available models (CSC and the clonal evolution model) need not be mutually exclusive to explain the origin of CSCs. | Turkish Journal of Biology Letter to the Editor Turk J Biol (2015) 39: 517-521 © TÜBİTAK doi: A letter in response to “Cancer stem cells: emerging actors in both basic and clinical cancer research” Turk J Biol (2014) 38: ©TÜBITAK – doi: Cancer stem cells (CSCs): targets and strategies for intervention Suresh Palamadai KRISHNAN* School of Bio Sciences and Technology, VIT University, Vellore, Tamil Nadu, India Received: Accepted/Published Online: Printed: Abstract: This letter to the editor highlights the important aspects of cancer stem cells and provides a deeper insight into the origin and characterization of these cells as well as the mechanisms contributing to drug resistance and relapse. The two currently available models (CSC and the clonal evolution model) need not be mutually exclusive to explain the origin of CSCs. The identification of CSCs (based on surface markers, drug efflux, enzyme activity, and signal transduction molecules and proteins involved in EMT processes) can help in discriminating these cells from other cell types. Moreover, CSCs prefer a hypoxic environment. This microenvironmental cue can trigger certain metabolic alterations that can orchestrate a rewiring of the epigenome. Consequently, changes in transcription factors and signaling molecules can contribute to the plasticity/inter-convertibility of the CSCs and non-CSC cellular states. Hence, an improved understanding of the mechanisms involved also provides opportunities for pharmacological manipulations. This letter also underscores the presence of precancerous stem cells as well as very small embryonic-like stem cells (VSELs) (both considered to be precursors of CSCs). These reports warrant a thorough reanalysis of the source of CSCs (lineage tracing studies), subsequent to the development of better targeted intervention approaches. Key words: Cancer stem cells, .

• Sinh học
• Cancer stem cells
• Precancerous stem cells
• Very small embryonic like stem cells
• Pharmacological strategies
• Drug resistance
• CD133+ cancer stem cells
• Ovarian cancer stem cells
• Ovarian cancer
• Boesenbergia pandurata
• Original ovarian cancer cells
• Leukemic stem cells
• Treatment of tumors
• Heterogeneous cell
• Leukemia elegantly
• BMC Cancer
• Mesothelioma stem cell
• RN5 EOS Puro2 cells
• Cancer cell repopulation
• Colon Cancer stem cells
• Tumor initiation
• Tumor xenografts
• Cancer stem like cells
• Larynx cancer
• Tumors including lung
• Stem cell associated signaling pathways
• Stem like cells
• Salivary gland malignant neoplasms
• Head and neck squamous cell carcinoma
• Mesenchymal stem cells
• Type 35 adenovirus fiber
• Human mesenchymal stem cells
• Coxsackie adenovirus receptor
• Dendritic cells
• Cytokine induced killer cells
• Hepatocellular carcinoma
• Caspase 3
• Liver cancer stem cells
• Breast cancer
• Cancer risk
• Familial cancer
• Stem cells
• Aldehyde dehydrogenase
• Cell fusion
• Gastric cancer
• Cancer progression
• Stem like cancer cells
• Cancer stem cell markers
• Flow cytometry
• Childhood intraocular malignant tumor
• Platelet activating factor
• Tumour microenvironment
• Anticancer activities of stichoposide D isolated
• The sea cucumber stichopus chloronotus
• Ntera 2 cancer stem cellsstem cells
• Stichopus chloronotus
• Circulating tumor cells
• Metastatic breast cancer
• Glioma stem cell
• Mesenchymal stem cell
• Glioma neovascularization
• Cancer stem like side population
• Oral cancer
• Eliminating cancer stem cells
• Tumor recurrence
• Cancer treatment
• Non small cell lung cancer
• Cell surface marker
• Cancer related lethality
• Mammosphere formation capacity
• Colony formation capacity
• ALDH1 positive cancer cells
• Glioblastoma stem cells
• HDAC inhibitors
• Patients with glioblastoma
• Cancer stem cell
• Isolation of cancer stem like cells
• Hepatocellular carcinoma cell line HepG2
• Magnetic activated cell sorting
• Anti tumor drug resistant selection
• Primary evaluation
• Cervical cancer stem cells
• Corresponding parental cells
• Sphere formation
• Non coding RNA molecules
• Cervical cancer
• Pathophysiological processes
• Several physiological
• PI3K Akt pathway
• Colon cancer
• Programmed cell death ligand 1
• Mediate cancer escape
• Cytometry analysis
• Lung cancer
• Cancer related mortality
• DNA damage