TAILIEUCHUNG - Mechanisms of pluripotency and epigenetic reprogramming in primordial germ cells: lessons for the conversion of other cell types into the stem cell lineage

Primordial germ cells (PGCs) provide an excellent tool to better understand ancestor–descendent relationships as well as the efficiency and molecular mechanisms governing pluripotency in the reprogramming of somatic cells, since the latter type of cells have a relatively lower efficiency of conversion to pluripotent cells. | Turkish Journal of Biology Review Article Turk J Biol (2015) 39: 187-193 © TÜBİTAK doi: Mechanisms of pluripotency and epigenetic reprogramming in primordial germ cells: lessons for the conversion of other cell types into the stem cell lineage Suresh PALAMADAI KRISHNAN* School of Bio Sciences & Technology, VIT University, Vellore, India Received: Accepted: Published Online: Printed: Abstract: Primordial germ cells (PGCs) provide an excellent tool to better understand ancestor–descendent relationships as well as the efficiency and molecular mechanisms governing pluripotency in the reprogramming of somatic cells, since the latter type of cells have a relatively lower efficiency of conversion to pluripotent cells. This kind of comparison has gained credence from the commonalities regarding the expression of key transcription factors such as octamer-binding transcription factor factor-4 (Oct3/4), SRY-related HMG box (Sox2), myelocytomatosis (c-Myc), and Nanog, as well as redundancy in terms of Kruppel-like factor 2 (Klf2), Kruppel-like factor 5 (Klf5), estrogen-related receptor beta (Esrrb), and estrogen-related receptor gamma (Esrrg) compensating for the absence of Kruppel-like factor 4 (Klf4). However, the exogenous addition of any one of these factors was found to be important, thereby implying that the expression level is important. L-Myelocytomatosis (L-myc) was shown to improve reprogramming efficiency without affecting tumorigenic potential. Molecular aspects of epigenetic reprogramming during the acquisition of pluripotency, as well as tumorigenic potential, have also been discussed, thus providing an understanding of the factors that can improve the former without increasing the possibility of neoplastic transformation. An improved understanding of the molecular events would pave the way for the development .

• Sinh học
• Primordial germ cells
• Stem cells
• Genetic reprogramming
• Transcription factors
• Induced pluripotent stem cells
• Embryonic germ cells
• Embryonic stem cells
• BMC Genomics
• Small non coding RNA
• Specific bioinformatics analyses
• Mito piRNAs
• Genome Biology
• DNA methylation
• Trans generational inheritance
• Certain epiphenotypes
• Pre implantation development
• Mesenchymal stem cells
• Stem cell based therapy
• Human embryonic stem cell
• Cancer stem cells
• Precancerous stem cells
• Very small embryonic like stem cells
• Pharmacological strategies
• Drug resistance
• Regenerative medicine
• Stem cells and regenerative medicine
• Nuclear reprogramming
• Stem cell fate
• BMC Molecular and Cell Biology
• Extracellular matrix
• Self renewal
• Self renewal capacity
• Multiple stem cell markers
• Single cell RNA seq
• Definitive endoderm
• Wave Crest
• Human pluripotent
• Stem cells into progenitor
• BMC Pediatrics
• Hematopoietic stem cells
• Peripheral blood circulating stem cells
• Blood testing
• Premature infants
• BMC Biotechnology
• Goat embryonic fibroblasts
• Goat iPS cells
• mRNA induced iPSCs formation
• Cell reprogramming
• Human embryonic stem cell N glycans
• N glycan core branching
• Human induced pluripotent stem cells
• Glycan binding proteins
• Dental pulp
• Cryopreserved dental pulp tissues
• Hepatocyte like cells
• Tạp chí khoa học
• Tạp chí sinh học
• Bovine embryonic stem cells
• Leukemia inhibitory factor
• Pluripotent genes
• Embryonic stem cell
• Sex conversion
• Germ cells
• Functional germ cells
• Chimeric mice produced
• BMC Cancer
• Human embryonic stem cells
• Familial adenomatous polyposis
• Adenomatous polyposis coli
• aPC gene
• Cyclin dependent kinases
• Apoptotic stimuli
• Cell based therapeutic purposes
• X chromosome
• Gene dosage
• Sex differences
• MAPK signaling
• H3K27 acetylation
• Gene transcription
• Enhancer activity
• Mouse embryonic stem cells
• Distal regulators
• Gene expression
• Complex network of enhancers
• Intracisternal A particles
• Ten eleven translocation enzymes
• Histone arginine methylation
• Human genomes
• Ten eleven translocation enzymes
• RNA methylation
• 5 Methylcytosine
• Mouse brain
• RNA binding proteins
• Bisulfite sequencing
• Heritable epigenetic mark
• Modifying cytosine
• Turkish Journal of Biology
• Morphological analysis
• Alkaline phosphatase staining
• Ebook Chemical
• Functional genomic approaches
• Stem cell biology
• Adult stem cells
• Cell fusion
• Hepatocellular carcinoma
• Stem cell
• Tumor initiating cell