TAILIEUCHUNG - Báo cáo y học: " Synovial fluid leukocyte apoptosis is inhibited in patients with very early rheumatoid arthriti"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Synovial fluid leukocyte apoptosis is inhibited in patients with very early rheumatoid arthritis. | Available online http content 8 4 R1 20 Research article Synovial fluid leukocyte apoptosis is inhibited in patients with very early rheumatoid arthritis Karim Raza1 2 Dagmar Scheel-Toellner1 Chi-Yeung Lee3 Darrell Pilling4 S John Curnow1 Francesco Falciani5 Victor Trevino5 Kanta Kumar1 2 Lakhvir K Assi1 Janet M Lord1 Caroline Gordon1 2 Christopher D Buckley1 2 and Mike Salmon1 1MRC Centre for Immune Regulation Division of Immunity and Infection The University of Birmingham Birmingham UK 2Department of Rheumatology City Hospital Sandwell and West Birmingham Hospitals NHS Trust Birmingham UK 3Department of Radiology City Hospital Sandwell and West Birmingham Hospitals NHS Trust Birmingham UK 4Department of Biochemistry and Cell Biology Rice University Houston Texas USA 5School of Biosciences The University of Birmingham Birmingham UK Corresponding author Karim Raza Received 30 May 2006 Revisions requested 26 Jun 2006 Revisions received 7 Jul 2006 Accepted 12 Jul 2006 Published 19 Jul 2006 Arthritis Research Therapy 2006 8 R120 doi ar2009 This article is online at http content 8 4 R120 2006 Raza et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Synovial leukocyte apoptosis is inhibited in established rheumatoid arthritis RA . In contrast high levels of leukocyte apoptosis are seen in self-limiting crystal arthritis. The phase in the development of RA at which the inhibition of leukocyte apoptosis is first apparent and the relationship between leukocyte apoptosis in early RA and other early arthritides has not been defined. We measured synovial fluid leukocyte apoptosis in very early arthritis and related this to clinical outcome.

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