TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 132

Pharmaceutical Substances Syntheses, Patents, Applications - Part 132. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Metixene M 1311 nh2 4-cooh HO CH3 2-methyl-L-serine 1. PBr5 2. NaOH NH2 r-J-COOH Br CHj L-2-amino 2-methyl-3-bromo-propionic acid from ethoxybromobenzene and sodium HBr VI Metirosine Reference s a Stein . et al. J. Am. Chem. Soc. JACSAT 77 700 1955 . US 2 868 818 Merck Co. appl. . b Potts . J. Chem. Soc. JCSOA9 1955 1632. c DOS 1 543 763 Merck Co. appl. USA-prior. . GB 1 105 103 Merck Co. appl USA-prior. . alternative syntheses enantioselective synthesis from L-tyrosine via the reaction product from A ơ-bis carbobenzoxy -L-tyrosine with benzaldehyde and its methylation US 4 508 921 Merck Co. appl. . DL-metirosine by reaction ö V A-dimethyl-4-hydroxybenzylamine with ethyl 2-nitropropionate Saari . J. Org. Chem. JOCEAH 32 4074 1967 . combination with carbidopa US 4 389 415 Merck Co. USA-prior. . EP 3 353 Merck Co. appl. 1979 USA-prior. . Formulation s cps. 250 mg Trade Name s GB Demser Merck Sharp USA Demser Merck Sharp Dohme wfm Dohme Metixene Methixene ATC N04AA03 Use antiparkinsonian antispasmodic RN. 4969-02-2 MF C2OH23NS MW EINECS 225-610-6 LD5o 18 mg kg M . 430 mg kg M . CN l-methyl-3- 9 7-thioxanthen-9-ylmethyl piperidine hydrochloride RN 1553-34-0 MF C20H23NS HC1 MW EINECS 216-300-1 LD50 18 mg kg M . 346 mg kg M . 24 mg kg R . 1460 mg kg R . hydrochloride monohydrate RN 7081-40-5 MF C20H23NS HC1 H2O MW 1312 M Metoclopramide thioxonthene NaNH2 3-chloromethyl- 1 -methylpiperidine Reference s US 2 905 590 The Wander Comp. prior. . Formulalion s tabl. mg 5 mg 15 mg as hydrochloride Trade Name s D Tremarit Novartis Pharma F Spasmenzyme Salvoxyl- Wander -comb. wfm GB Tremonil Wander wfm Tremonil Sandoz as hydrochloride hydrate wfm I Tremaril Sandoz J Atosil Teisan Cholinfall Tokyo Tanabe Dalpan Grelan Methyloxan Nippon Shoji- Kodama Thioperkin Hokuriku USA Trest .

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