TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 25

Pharmaceutical Substances Syntheses, Patents, Applications - Part 25. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Bicalutamide B 241 Bicalutamide ICI-176334 ATC L02BB03 Use non-steroidal antiandrogen antineoplastic anti prostate cancer RN 90357-06-5 MF C 8H14F4N2O4S MW CN -N- 4-cyano-3- trifluoromethyl phenyl -3- 4-fluorophenyl sulfonyl -2-hydroxy-2-methylpropanamide R-enantiomer RN 113299-40-4 MF C18H14F4N2O4S MW 5-enantiomer RN 113299-38-0 MF C18H14F4N2O4S MW 9 p H2 2 NoOH 9 PH NoH THF --------- h3cvV 3----------------------- CH2 0- 4-fluoro- thiophenol I methyl methyl methocrylate 2-methylpropionote methyl 2-hydroxy-2-methyl-3- 4-fluora-phenylthio propionote II h2n cf3 SOCI2 H3C-CO-N CH3 2 CN 4-cyano-3-trifluoromethyl-oniiine III thianyl chloride DMA N- 4-cyano-3-trifluoromethylphenyl - 3- 4-fluorophenylsulfonyl -2-hydroxy-2-methylpropionamide IV 3-chloroper-benzoic acid V h3c-co-n ch3 2 ---------------- V VI methacryloyl chloride 4 -cyano-3 -trifluoro-methylmethacryl- nilide NoH THF W ----------- IV ---------- Bicalutamide I 4 -cyano-3 -trifluoro-methyl-2 3-epoxy-2-methyl-propionaniiide VI B 242 Bietamiverine Reference s EP 100 172 ICI appl. UK-prior. . active enantiomer R- - -bicalutamide for treating e. g. prostate cancer acne WO 9 519 770 Sepracor Inc. appl. USA-prior. . combination with progesterone antagonists DE 4 318 371 Schering AG D-prior. . combination with sex steroid biosynthesis inhibitors WO 9 100 733 Endorecherche Inc. USA-prior. . Formulation s tabl. 50 mg Trade Name s D Casodex Zeneca GB Casodex Zeneca USA Casodex Zeneca Bietamiverine Dietamiverin ATC A03AA Use antispasmodic RN 479-81-2 MF C19H30N2O2 MW EINECS 207-538-7 CN a-phenyl-1-piperidineacetic acid 2- diethylamino ethyl ester dihydrochloride RN 2691-46-5 MF C19H30N2O2 2HC1 MW EINECS 220-262-1 LD50 55 mg kg M . 1247 mg kg M . rCH3 ho n-ch3 2-phenyl-2-chloroacetic acid 2- diethylamina ethyl ester I a-chlorophenyl- 2-diethylamino- acetyl chloride ethanol piperidine Reference

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