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Pharmaceutical Substances Syntheses, Patents, Applications - Part 25. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Bicalutamide B 241 Bicalutamide ICI-176334 ATC L02BB03 Use non-steroidal antiandrogen antineoplastic anti prostate cancer RN 90357-06-5 MF C 8H14F4N2O4S MW 430.38 CN -N- 4-cyano-3- trifluoromethyl phenyl -3- 4-fluorophenyl sulfonyl -2-hydroxy-2-methylpropanamide R-enantiomer RN 113299-40-4 MF C18H14F4N2O4S MW 430.38 5-enantiomer RN 113299-38-0 MF C18H14F4N2O4S MW 430.38 9 p H2 2 NoOH 9 PH NoH THF --------- h3cvV 3----------------------- CH2 0- 4-fluoro- thiophenol I methyl methyl 2.3-epoxy- methocrylate 2-methylpropionote methyl 2-hydroxy-2-methyl-3- 4-fluora-phenylthio propionote II h2n cf3 SOCI2 H3C-CO-N CH3 2 CN 4-cyano-3-trifluoromethyl-oniiine III thianyl chloride DMA N- 4-cyano-3-trifluoromethylphenyl - 3- 4-fluorophenylsulfonyl -2-hydroxy-2-methylpropionamide IV 3-chloroper-benzoic acid V h3c-co-n ch3 2 ---------------- V VI methacryloyl chloride 4 -cyano-3 -trifluoro-methylmethacryl- nilide NoH THF W ----------- IV ---------- Bicalutamide I 4 -cyano-3 -trifluoro-methyl-2 3-epoxy-2-methyl-propionaniiide VI B 242 Bietamiverine Reference s EP 100 172 ICI appl. 8.7.1983 UK-prior. 23.7.1982 . active enantiomer R- - -bicalutamide for treating e. g. prostate cancer acne WO 9 519 770 Sepracor Inc. appl. 27.7.1995 USA-prior. 21.1.1994 . combination with progesterone antagonists DE 4 318 371 Schering AG 1.12.1994 D-prior. 28.5.1993 . combination with sex steroid biosynthesis inhibitors WO 9 100 733 Endorecherche Inc. 24.1.1994 USA-prior. 7.7.1989 . Formulation s tabl. 50 mg Trade Name s D Casodex Zeneca GB Casodex Zeneca USA Casodex Zeneca Bietamiverine Dietamiverin ATC A03AA Use antispasmodic RN 479-81-2 MF C19H30N2O2 MW 318.46 EINECS 207-538-7 CN a-phenyl-1-piperidineacetic acid 2- diethylamino ethyl ester dihydrochloride RN 2691-46-5 MF C19H30N2O2 2HC1 MW 391.38 EINECS 220-262-1 LD50 55 mg kg M i.v. 1247 mg kg M p.o. rCH3 ho n-ch3 2-phenyl-2-chloroacetic acid 2- diethylamina ethyl ester I a-chlorophenyl- 2-diethylamino- acetyl chloride ethanol piperidine Reference
