TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 34

Pharmaceutical Substances Syntheses, Patents, Applications - Part 34. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Canthaxanthin C 331 NBS AcOH chci3 ---------- 4-acetoxyretinal I retinal cf. betacaratene synthesis trans-isozeaxanthin HI Reference s US 3 311 656 Roche appl. . Surmatis . et al. Helv. Chim. Acta HCACAV 53 974 1970 . alternative syntheses DOS 2 037 935 Roche appl. CH-prior. . US 4 000 198 Roche appl. . DOS 2 625 259 Roche appl. USA-prior. . Formulation s gel 10 mg 600 mg 15 mg 900 mg 332 C Capecitabine Trade Name s F Phenoro Roche Prod. Roche . -comb. with betacarotene Capecitabine Ro-09-1978 ATC L01BC06 Use anticancer orally active prodrug of doxifluridine RN 154361-50-9 MF C15H22FN3O6 MW CN 5 -Deoxy-5-fluoro-7V- pentyloxy carbonyl cytidine doxifluridine . 5 -deoxy-5-fluoro-cytidine I H3Cvff 0vtf CH3 0 0 pyridine 0 C ----------------- 2 -3 -di-O-acetyl-5 -deoxy-5-fluoro-cytidîne II Capreomycin C 333 I in 1. NoOH CH-jOH -10 C 2. HCI ----------------- alternative preparation of intermediate II 5-fluoro-cytosine H3c CH3H3C CHj si h cz tv ch 3 H 3 CH CH3 3 5-fluoro-2-0 4-N-bis- trimethyisilyl cytasine V Capecitabine hexamethyldisilazane H3cXx O o ch n r 0 2. H20 H V------------------------------k- n 1. 1 2 3-triacetyl-5- deoxy-p-D-ribofuronose Reference s a EP 602 454 Hoffmann-La Roche appl. EP-prior. US 5 472 949 Hoffmann-La Roche EP-prior. . b US 5 476 932 Hoffmann-La Roche USA-prior. compositions of interleukin and pyrimidine nucleosides W09 637 214 Hoffmann-La Roche appl. EP-prior. Formulation s tabl. 150 mg 500 mg Trade Name s USA Xeloda Roche 1998 Capreomycin Caprenomycin ATC J04AB30 Use tuberculostatic peptide antibiotic RN 11003-38-6 MF C H N Og MW LDjo 238 mg kg M . CN capreomycin mixture of capreomycin IB IA IIA and IIB sulfate RN 1405-37-4 MF H2SO4 unspecified MW unspecified EINECS 215-776-8 LDJ 250 mg kg M . 325 mg kg R .

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