TAILIEUCHUNG - Ebook Clinical chemistry - Quality in laboratory diagnosis: Part 2

(BQ) Part 2 book "Clinical chemistry - Quality in laboratory diagnosis" presents the following contents: Endocrine/tumor markers/special chemistry; laboratory information systems/informatics, laboratory safety, outreach testing. | Endocrine Tumor Markers Special Chemistry Overview 95 Preanalytical Errors 96 Analytical Errors 103 Postanalytical Errors 105 Standards of Care 106 Recommended Reading 107 OVERVIEW Endocrine testing concerns the analysis of hormones peptides and other compounds secreted by the glands of the body. Hormones can be proteins like thyroid-stimulating hormone and parathyroid hormone or smaller molecules like thyroxine or cortisol. Endocrine tests sometimes measure a hormone directly but in other instances may analyze compounds affected by hormones. For example in diabetes mellitus primarily a disease of insulin deficiency or insufficient insulin action at tissue receptors clinicians diagnose and manage the disorder through analysis of glucose levels rather than through direct measurement of circulating insulin levels. Endocrine tests are utilized to diagnose and manage disorders of the pituitary thyroid parathyroid adrenal ovary testes and other organs of the body. Due to the variety of different compounds related to endocrine function testing for endocrine disorders involves a variety of methodologies. Competitive immunoassays that rely on the binding of hormones and metabolites to specific antibodies in the test reagent are often utilized. Glucose is measured by enzyme-specific reagents with colorimetric endpoints. Immunoassays and spectrophotometric assays can be automated on laboratory instrumentation but 96 5. Endocrine Tumor Markers Special Chemistry more manual methods such as radioimmunoassay and enzyme-linked immunosorbent assays are also employed for analysis of hormones and compounds. Failure to follow basic laboratory practices with specimen labeling collection transportation analysis and result reporting can lead to test result errors. In addition some hormones and compounds are unstable in patient samples so appropriate specimen collection and handling are of particular concern to ensure accurate detection and quantitation of the amount of hormone in the .

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• Clinical chemistry
• Quality in laboratory diagnosis
• Laboratory information systems
• Laboratory safety
• Outreach testing
• Special chemistry
• Biotechnology and clinical chemistry
• Biological preparations
• Allosteric enzymes
• Sigmoidal behaviour
• Specimen receiving and processing
• Core chemistry
• Point of Care testing
• Therapeutic drug monitoring
• Clinical diagnostic tests
• Clinical microbiology
• Laboratory management
• Patient safety
• Organ function tests
• Laboratory investigation
• Laboratory investigations
• Inborn metabolic diseases
• Inborn errors of metabolism
• Iron deficiency anaemia
• Renal function tests
• Tietz fundamentals of clinical chemistry Molecular diagnostics
• Principles of laboratory medicine
• Analytical techniques
• Optical techniques
• Quality management
• Serum enzymes
• Tietz fundamentals of clinical chemistry
• Molecular diagnostics
• Reference information
• Porphyrins and Porphyrias
• Thyroid Disorders
• Journal of medical research
• Production of liophilized quality control samples
• Liophilized quality control samples
• Several clinical chemistry test
• Statistical quality control
• The structure of proteins
• The biosynthesis
• Oligomeric enzymes
• Enzyme inhibition
• Enzyme catalysed reactions
• Textbook of biochemistry
• Chemical basis of life
• General metabolism
• Clinical and applied biochemistry
• Applied biochemistry
• Chemistry of lipids
• Chemistry of carbohydrates
• Overview of metabolism
• Chemical Modification
• Analytical Technologies
• Validation Issues
• Diagnostic Development
• Clinical Proteomics
• Interpreting Blood Results
• Overview of tests
• liquid component
• Autoimmune and inflammation
• Full Blood Count
• Chemistry
• analysis involves
• dvanced chemistry
• Laboratory Parameters
• Clinical Outcome
• Response to Anti
• Alpha Treatment
• Epidermal Lipids
• Hyperkeratotic Conditions
• Barrier Homeostasis
• Skin Physiology
• Atopic Dermatitis
• Hydrophilic Pastes
• Reference range values for pediatric care
• Scales and scoring
• Blood pressure
• Reference range values
• Temperature conversion