TAILIEUCHUNG - Báo cáo khoa học: "Stratification, Blinding and Placebo Effect in a Randomized, Double Blind Placebo-controlled Clinical Trial of Gold Bead Implantation in Dogs with Hip Dysplasia"

Tuyển tập các báo cáo nghiên cứu về bệnh thú y được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành thú y đề tài: Stratification, Blinding and Placebo Effect in a Randomized, Double Blind Placebo-controlled Clinical Trial of Gold Bead Implantation in Dogs with Hip Dysplasia. | Acta vet. scand. 2005 46 57-68. Stratification Blinding and Placebo Effect in a Randomized Double Blind Placebo-controlled Clinical Trial of Gold Bead Implantation in Dogs with Hip Dysplasia By G. T. Jager S. Larsen2 and L. Moe3 Department of Companion Animal Clinical Sciences 2Department of Production Animal Clinical Sciences 1 2 3Norwegian School of Veterinary Science Oslo Norway. Jffiger GT Larsen S Moe L Stratification Blinding and Placebo Effect in a Randomized Double Blind Placebo-controlled Clinical Trial of Gold Bead Implantation in Dogs with Hip Dysplasia. Acta vet. Scand. 2005 46 57-68. - The purpose of this study was to investigate the need for and choice of stratification factors and the effects of blinding and placebo in a clinical experiment. Eighty dogs with canine hip dysplasia CHD were included in a randomized placebo-controlled and double blind clinical trial with stratified parallel group design in which body weight and degree of CHD were used as stratification factors. Thirty-eight dogs were allocated to gold bead implantation and 42 to placebo. After six months 33 of the 42 placebo-treated dogs received gold bead implantation in an open study lasting a further 18 months. The main outcome variable in the study was change in pain signs of CHD as assessed by the owner. No significant difference in the main outcome variable regardless of the treatment given could be detected in the two chosen stratification factors. The only factor to influence the main outcome variable significantly was age. The blinding procedure used in the study in which 60 of the owners correctly guessed the treatment given was found sufficient. Of those who guessed the treatment erroneously 88 believed the treatment given was gold bead implantation. The treatment efficacy after six months in the blinded treatment group was found to be significantly larger compared to the efficacy obtained in the open study. A significant placebo effect was therefore detected. Conclusion and .

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