TAILIEUCHUNG - Báo cáo y học: "Could the expression of CD86 and FcγRIIB on B cells be functionally related and involved in driving rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Could the expression of CD86 and FcγRIIB on B cells be functionally related and involved in driving rheumatoid arthritis? | Mauri and Jury Arthritis Research Therapy 2010 12 133 http content 12 4 133 EDITORIAL Could the expression of CD86 and FcyRIIB on B cells be functionally related and involved in driving rheumatoid arthritis Claudia Mauri and Elizabeth C Jury See related research by Catalan et al. http content 12 2 R68 Abstract Aberrant immune responses play a pivotal role in the processes that cause inflammation and joint damage in patients with rheumatoid arthritis RA . Polyclonal B cell activation and the production of autoantibodies are immunological hallmarks of the disease. However controversy surrounds the pathogenicity of autoantibodies mainly because not all patients are seropositive 10 of RA patients are seronegative suggesting that they could be markers rather than makers of disease. Catalan and collaborators report that patients with RA display reduced expression of FcyRIIB on memory B cells and plasma cells which inversely correlates with autoantibody levels. Considering that FcyRIIB stimulation down-regulates antibody production this work strengthens the link between autoantibodies and pathogenicity. In a recent article Catalan and colleagues 1 examined the expression of FcyRIIB in naive memory and plasmablast B cell subsets from peripheral blood of patients with rheumatoid arthritis RA and the results were correlated with levels of autoantibodies to cyclic citrullinated proteins anti-CCP detected in matching serum. Firstly they observed reduced FcyRIIB expression in memory and plasmablast B cells from patients compared to the levels expressed on B cells from healthy controls. Secondly the expression levels of FcyRIIB inversely correlated with the titre of anti-CCP antibodies in patients serum. Indeed RA patients with low autoantibody titres expressed higher levels of this receptor. 1 Thirdly they also report an increased frequency of CD86 Correspondence Centre for Rheumatology Research Department of .

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