TAILIEUCHUNG - Báo cáo y học: " Adult onset lung disease following transient disruption of fetal stretch-induced differentiation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Adult onset lung disease following transient disruption of fetal stretch-induced differentiation. | Respiratory Research BioMed Central Research Adult onset lung disease following transient disruption of fetal stretch-induced differentiation Joseph J Hudak Erin Killeen Ashok Chandran J Craig Cohen and Janet E Larson Address The Brady Laboratory Section of Neonatology Department of Pediatrics Stony Brook University School of Medicine Stony Brook New York 11794 USA Email Joseph J Hudak - Erin Killeen - Ashok Chandran - ashokchandran90@ J Craig Cohen - Janet E Larson - jlarson@ Corresponding author Open Access Published 6 May 2009 Received 15 September 2008 Respiratory Research 2009 10 34 doi l465-992l-l0-34 Accepted 6 May 2009 This article is available from http content l0 l 34 2009 Hudak et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract One of the mechanisms by which adult disease can arise from a fetal origin is by in utero disruption of organogenesis. These studies were designed to examine respiratory function changes in aging rats following transient disruption of lung growth at 16 days gestation. Fetuses were treated in utero with a replication deficient adenovirus containing the cystic fibrosis conductance transmembrane regulator CFTR gene fragment cloned in the anti-sense direction. The in utero-treated rats demonstrated abnormal lung function beginning as early as 30 days of age and the pathology progressed as the animals aged. The pulmonary function abnormalities included decreased static compliance as well as increased conducting airway resistance tissue damping and elastance. Pressure volume PV curves demonstrated a slower early rise to volume and air trapping at .

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