TAILIEUCHUNG - Báo cáo y học: " Mechanisms of the noxious inflammatory cycle in cystic fibrosis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"" Mechanisms of the noxious inflammatory cycle in cystic fibrosis. | Respiratory Research BioMed Central Open Access Review Mechanisms of the noxious inflammatory cycle in cystic fibrosis Mathilde Rottner1 2 Jean-Marie Freyssinet1 2 and M Carmen Martinez 3 Address 1INSERM U 770 Université Paris-Sud 11 Faculté de Médecine Hôpital de Bicêtre Le Kremlin-Bicêtre France 2Université Louis Pasteur Faculté de Médecine Institut d Hématologie et d lmmunologie Strasbourg France and 3CNRS UMR 6214 INSERM U 771 Université d Angers Angers France Email Mathilde Rottner - Jean-Marie Freyssinet - M Carmen Martinez - Corresponding author Published 13 March 2009 Received 16 January 2009 Respiratory Research 2009 10 23 doi l465-992l-l0-23 Accepted I3 March 2009 This article is available from http content l0 l 23 2009 Rottner et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Multiple evidences indicate that inflammation is an event occurring prior to infection in patients with cystic fibrosis. The self-perpetuating inflammatory cycle may play a pathogenic part in this disease. The role of the NF-kB pathway in enhanced production of inflammatory mediators is well documented. The pathophysiologic mechanisms through which the intrinsic inflammatory response develops remain unclear. The unfolded mutated protein cystic fibrosis transmembrane conductance regulator CFTRAF508 accounting for this pathology is retained in the endoplasmic reticulum ER induces a stress and modifies calcium homeostasis. Furthermore CFTR is implicated in the transport of glutathione the major antioxidant element in cells. CFTR mutations can alter redox homeostasis and induce an .

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