TAILIEUCHUNG - Báo cáo y học: "The role of leptin in innate and adaptive immune responses"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The role of leptin in innate and adaptive immune responses. | Available online http content 8 5 217 Review The role of leptin in innate and adaptive immune responses Eiva Bernotiene1 Gaby Palmer2 3 and Cem Gabay2 3 1 Department of Experimental Research Institute of Experimental and Clinical Medicine Vilnius University Vilnius Lithuania 2Division of Rheumatology Department of Internal Medicine University Hospital Geneva Switzerland 3Department of Pathology and Immunology University of Geneva School of Medicine Geneva Switzerland Corresponding author Cem Gabay Published 28 July 2006 This article is online at http content 8 5 217 2006 BioMed Central Ltd Arthritis Research Therapy 2006 8 217 doi ar2004 Abstract Leptin is produced primarily by adipocytes and functions in a feedback loop regulating body weight. Leptin deficiency results in severe obesity and a variety of endocrine abnormalities in animals and humans. Several studies indicated that leptin plays an important role in immune responses. It exerts protective anti-inflammatory effects in models of acute inflammation and during activation of innate immune responses. In contrast leptin stimulates T lymphocyte responses thus having rather a proinflammatory role in experimental models of autoimmune diseases. Clinical studies have so far yielded inconsistent results suggesting a rather complex role for leptin in immune-mediated inflammatory conditions in humans. Introduction Leptin is a 16 kDa peptide hormone with the tertiary structure of a cytokine that is highly conserved among mammalian species 1 . It is structurally and functionally related to the IL-6 cytokine family. Leptin functions as a signal in a feedback loop regulating food intake and body weight 2 . The leptin receptor Ob-R or Lepr is a member of the class I cytokine receptor family which includes gp-130 the common signal transducing receptor for the IL-6 related family of cytokines 3 . Alternative splicing of the leptin receptor gene .