TAILIEUCHUNG - Báo cáo y học: "Deficiency of functional mannose-binding lectin is not associated with infections in patients with systemic lupus erythematosu"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Deficiency of functional mannose-binding lectin is not associated with infections in patients with systemic lupus erythematosus. | Available online http content 8 6 R183 Research article Deficiency of functional mannose-binding lectin is not associated with infections in patients with systemic lupus erythematosus Irene EM Bultink1-2-3 Dorte Hamann4 Marc A Seelen5 Margreet H Hart4 Ben AC Dijkmans1 2 3 Mohamed R Daha5 and Alexandre E Voskuyl1 Department of Rheumatology VU University Medical Center Postbox 7057 Amsterdam 1007 MB The Netherlands 2Slotervaart Hospital Louwesweg 6 Amsterdam 1066 EC The Netherlands 3Jan van Breemen Institute Dr J. van Breemenstraat 2 Amsterdam 1056 AB The Netherlands 4Sanquin Research at CLB Plesmanlaan 1 25 Amsterdam 1066 CX The Netherlands department of Nephrology Leiden University Medical Center Postbox 9600 Leiden 2300 RC The Netherlands Corresponding author Irene EM Bultink iem_bultink@ Received 17 Jun 2006 Revisions requested 8 Aug 2006 Revisions received 9 Sep 2006 Accepted 13 Dec 2006 Published 13 Dec 2006 Arthritis Research Therapy 2006 8 R183 doi ar2095 This article is online at http content 8 6 R183 2006 Bultink et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Infection imposes a serious burden on patients with systemic lupus erythematosus SLE . The increased infection rate in SLE patients has been attributed in part to defects of immune defence. Recently the lectin pathway of complement activation has also been suggested to play a role in the occurrence of infections in SLE. In previous studies SLE patients homozygous for mannose-binding lectin MBL variant alleles were at an increased risk of acquiring serious infections in comparison with patients who were heterozygous or homozygous for the normal allele. This association

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