TAILIEUCHUNG - Báo cáo y học: "Biology of recently discovered cytokines: Discerning the pro- and anti-inflammatory properties of interleukin-27"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Biology of recently discovered cytokines: Discerning the pro- and anti-inflammatory properties of interleukin-27. | Available online http content 6 5 225 Review Biology of recently discovered cytokines Discerning the pro- and anti-inflammatory properties of interleukin-27 Alejandro V Villarino and Christopher A Hunter Department of Pathobiology School of Veterinary Medicine University of Pennsylvania Philadelphia Pennsylvania USA Corresponding author Christopher A Hunter chunter@ Received 25 Jun 2004 Accepted 21 Jul 2004 Published 16 August 2004 Arthritis Res Ther 2004 6 225-233 DOI ar1227 2004 BioMed Central Ltd Abstract IL-27 is a recently identified heterodimeric cytokine produced in response to microbial and host derived inflammatory cues. Initial studies indicated that IL-27 promotes the generation of Th1 responses required for resistance to intracellular infection and unveiled the molecular mechanisms mediating this effect. However subsequent work uncovered a role for IL-27 in the suppression of Th1 and Th2 responses. Thus by discussing its pleotropic functions in the context of infection-induced immunity and by drawing parallels to fellow IL-6 IL-12 family cytokines this review will attempt to reconcile the pro- and anti-inflammatory effects of IL-27. Keywords IL-27 WSX-1 Th1 Th2 infection Introduction IL-27 is a heterodimeric member of the IL-6 IL-12 family of type I cytokines 1 2 . Like IL-12 and IL-23 1 IL-27 is the pairing of a helical protein IL-27p28 with a soluble cytokine receptor-like component Epstein-Barr virus-induced gene 3 EBI3 Fig. 1 1 3 . Similar to IL-12p40 and soluble forms of IL-6 receptor components 4 EBI3 contains two cytokine binding domains but lacks membrane anchoring motifs and a cytoplasmic tail Fig. 1 5 . Originally identified as an IL-12p40 homolog that is secreted by Epstein-Barr virus EBV transformed B cells 5 EBI3 is produced by a range of immune cell lineages including B cells monocytes dendritic cells DCs and epithelial cells 3 5-7 . While typically low or absent in resting cells EBI3 .

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