TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 57

Pharmaceutical Substances Syntheses, Patents, Applications - Part 57. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Cyclopenthiazide C 561 Reference s US 2 520 015 Eli Lilly 1950 prior. 1948 . Formulation s amp. 10 mg 25 mg sol. Trade Name s D Copyronilum Lilly - F Cyclonarol Hépatrol comb. wfm wfm I Copyronil Lilly wfm USA Clopane Lilly wfm Cyclopenthiazide Cyclomethiazide ATC C03AA07 Use diuretic antihypertensive RN 742-20-1 MF C13H18C1N3O4S2 MW EINECS 212-012-5 LDS0 232 mg kg M . 1 g kg M . 142 mg kg R . 1 g kg R . CN 6-chloro-3- cyclopentylmethyl -3 4-dihydro-2 7-1 2 4-benzothiadiazine-7-sulfonamide 1 1 -dioxide 6-omino-4-chloro-1 3-benzenedisulf amide cf. chlorothiazide synthesis OHC cyclopentylacetaldehyde Reference s BE587 225 Ciba appl. USA-prior. . Whitehead . et al. J. Org. Chem. JOCEAH 26 2814 1961 . Formulation s tabl. mg mg Trade Name s D Navidrex Ciba wfm GB Navidrex Novartis J Navispare Novartis -comb. Trasidrex Novartis -comb. Navidrex Ciba-Geigy- Takeda USA Navidrix Ciba-Geigy wfm Cyclopentobarbital ATC N05CA Use hypnotic RN 76-68-6 MF C12H14N2O3 MW EINECS 200-979-6 LDjo 90 mg kg R . CN 5- 2-cyclopenten-l-yl -5- 2-propenyl -2 4 6 lW 3H 5 f -pyrimidinetrione A Ö 3-bromo- cyclopentene OyO CHj 0 diethyl molonote NaOC2H5 diethyl 2-cyclo- pentenylmalonate H2C N_Br . NoOC2H --------or---------- j allyl bromide 562 C Cyclopentolate H2hkyO nh2 NaOC2H5 diethyl ollyl- urea 2-cyclopentenyl -malonote Reference s DRP 589 947 Comp de Béthune appl. 1930 F-prior. 1929 . Trade Name s D Cyclopal Siegfried wfm Cyclopentolate atc. soifao4 Use antispasmodic mydriatic RN 512-15-2 MF C17H25NO3 MW EINECS 208-136-4 CN a- l-hydroxycyclopentyl benzeneacetic acid 2- dimethylamino ethyl ester hydrochloride RN 5870-29-1 MF C17H25NO3 HC1 MW EINECS 227-521-8 LD50 84 mg kg M . 960 mg kg M . 4 g kg R . h3c ch3 Br Mg --- isopropyl bromide sodium phenyl- cyclo- a- l-hydroxy- acetate pentanane cyclopen tyl - phenylacetic acid 1 2- dimethyl-amino ethyl chloride Reference s US 2 554 511 Schieffelin Co. 1951 prior. 1949

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