TAILIEUCHUNG - Báo cáo khoa học: Aedes aegypti ferritin A cytotoxic protector against iron and oxidative challenge?

Diseases transmitted by hematophagous (blood-feeding) insects are responsible for millions of human deaths world-wide. Inhematophagous insects, thebloodmeal is important for regulating egg maturation. Although a high concentra-tion of iron is toxic for most organisms, hematophagous insects seemunaffectedby the iron load means by which hematophagous insects handle this iron load is, perhaps, by the expression of iron-binding proteins, specifically the iron storage protein ferritin | Eur. J. Biochem. 270 3667-3674 2003 FEBS 2003 doi Aedes aegypti ferritin A cytotoxic protector against iron and oxidative challenge Dawn L. Geiser1 2 Carrie A. Chavez3 Roberto Flores-Munguia1 Joy J. Winzerling1 2 and Daphne . Pham3 1 Department of Nutritional Sciences College of Agriculture and Life Sciences and 2Center for Insect Science The University of Arizona Tucson AZ USA 3Department of Biological Sciences University of Wisconsin-Parkside Kenosha WI USA Diseases transmitted by hematophagous blood-feeding insects are responsible for millions of human deaths worldwide. In hematophagous insects the blood meal is important for regulating egg maturation. Although a high concentration of iron is toxic for most organisms hematophagous insects seem unaffected by the iron load in a blood meal. One means by which hematophagous insects handle this iron load is perhaps by the expression of iron-binding proteins specifically the iron storage protein ferritin. In vertebrates ferritin is an oligomer composed of two types of subunits called heavy and light chains and is part of the constitutive antioxidant response. Previously we found that the insect midgut a main site of iron load is also a primary site of ferritin expression and that in the yellow fever mosquito Aedes aegypti the expression of the ferritin heavy-chain homologue HCH is induced following blood feeding. We now show that the expression of the Aedes ferritin light-chain homologue LCH is also induced with blood-feeding and that the genes of the LCH and HCH are tightly clustered. mRNA levels for both LCH- and HCH-genes increase with iron H2O2 and hemin treatment and the temporal expression of the genes is very similar. These results confirm that ferritin could serve as the cytotoxic protector in mosquitoes against the oxidative challenge of the bloodmeal. Finally although the Aedes LCH has no iron responsive element IRE at its 5 -untranslated region UTR the 5 -UTR contains .

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