TAILIEUCHUNG - Guidelines for the Management of Inflammatory Bowel Disease in Children in the United Kingdom

Red blood cells contain hemoglobin. Hemoglobin helps red blood cells carry oxygen from the lungs to other parts of the body. People with normal hemoglobin have mostly Hemoglobin A in their red blood cells. People with sickle cell disease have mostly sickle or Hemoglobin S (Hb S) in their red blood cells. Hb S is an abnormal type of hemoglobin. In people with sickle cell disease, Hb S causes the red blood cells to change from a round shape to a sickle or banana shape. Also, Hb S causes the red blood cells to become rigid and sticky. This leads. | Guidelines Guidelines for the Management of Inflammatory Bowel Disease in Children in the United Kingdom Bhupinder K. Sandhu John . Fell zR. Mark Beattie Sally G. Mitton jDavid C. Wilson and Huw Jenkins on Behalf of the IBD Working Group of the British Society of Paediatric Gastroenterology Hepatology and Nutrition JPGN 2010 50 S1-S13 INTRODUCTION 1 Inflammatory bowel disease IBD encompasses 2 related but distinct disorders of as yet unknown aetiology. Crohn disease CD is a chronic idiopathic transmural inflammation that can affect 1 or several segments of the digestive tract. Ulcerative colitis UC is a chronic idiopathic inflammation of the rectum extending continuously over a variable length of the colon from the distal end to the proximal end. indeterminate colitis iC is reserved for cases of colitis for which findings are not sufficient to allow differentiation between CD and UC 1 . Development of Guidelines 2-4 These guidelines are the work of the iBD Working Group of the British Society of Paediatric Gastroenterology Hepatology and Nutrition BSPGHAN and are for use by clinicians and allied professionals caring for children with iBD in the United Kingdom. There is a paucity of paediatric trials of high methodological quality to provide a comprehensive evidence-based document. Thus these clinical guidelines have had to be consensus based informed by the best-available evidence from the paediatric literature and high-quality data from the adult iBD literature together with the clinical expertise and multidisciplinary experience of iBD experts comprising paediatric gastroenterologists represented by BSPGHAN. They provide an evidence- and consensus-based document describing good clinical practice for the investigation and treatment of iBD in children which will promote consistency of the management of such conditions. individual cases must be managed on the basis From the Department of Paediatric Gastroenterology Bristol Royal Hospital for Children .

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