TAILIEUCHUNG - Protein C concentrations in severe sepsis: an early directional change in plasma levels predicts outcome

of Medicine, Section of Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC, USA of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee, USA 3Department of Intensive Care and Emergency Medicine, Cochin-Port Royal University Hospital, Paris 5 René Descartes University, Paris, France 4Critical Care Research, St Paul's Hospital and University of British Columbia McDonald Research Laboratories, Vancouver, Canada 5Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, Indiana, USA 2Department Corresponding author: Andrew F Shorr, afshorr@ Received:. | Available online http content 10 3 R92 Research Protein C concentrations in severe sepsis an early directional change in plasma levels predicts outcome Andrew F Shorr1 Gordon R Bernard2 Jean-Francois Dhainaut3 James R Russell4 William L Macias5 David R Nelson5 and David P Sundin5 Open Access Department of Medicine Section of Pulmonary and Critical Care Medicine Washington Hospital Center Washington DC USA department of Medicine Division of Allergy Pulmonary and Critical Care Medicine Vanderbilt University Nashville Tennessee USA department of Intensive Care and Emergency Medicine Cochin-Port Royal University Hospital Paris 5 René Descartes University Paris France 4Critical Care Research St Paul s Hospital and University of British Columbia McDonald Research Laboratories Vancouver Canada 5Lilly Research Laboratories Eli Lilly and Co. Indianapolis Indiana USA Corresponding author Andrew F Shorr afshorr@ Received 27 Mar 2006 Revisions requested 18 Apr 2006 Revisions received 23 Apr 2006 Accepted 1 2 May 2006 Published 15 Jun 2006 Critical Care 2006 10 R92 doi cc4946 This article is online at http content 10 3 R92 2006 Shorr et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Protein C because of its central role in hemostasis plays an integral role in the host response to infection. Protein C depletion resulting from increased consumption degradation and or decreased synthesis is characteristic of sepsis and has been shown to predict morbidity and mortality. The objective of this study was to determine whether early directional changes in protein C levels correlate with outcome. Methods Patients in the Recombinant Human Activated Protein C Worldwide Evaluation

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