TAILIEUCHUNG - Genetic polymorphisms of matrix metalloproteinases and their inhibitors in potentially malignant and malignant lesions of the head and neck

Abstract Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are capable of cleaving all extra cellular matrix (ECM) substrates. Degradation of matrix is a key event in progression, invasion and metastasis of potentially malignant and malignant lesions of the head and neck. It might have an important polymorphic association at the promoter regions of several MMPs such as MMP-1 (-1607 1G/2G), MMP-2 (-1306 C/T), MMP-3 (-1171 5A/6A), MMP-9 (-1562 C/T) and TIMP-2 (-418 G/C or C/C) | Chaudhary et al. Journal of Biomedical Science 2010 17 10 http content 17 1 10 I NSC The cost of publication in Journal of Biomedical Science is bourne by the National Science Council Taiwan. JOURNAL OF BIOMEDICAL SCIENCE REVIEW Open Access Genetic polymorphisms of matrix metalloproteinases and their inhibitors in potentially malignant and malignant lesions of the head and neck Ajay Kumar Chaudhary1 2 Mamta Singh2 Alok C Bharti3 Kamlesh Asotra4 Shanthy Sundaram1 and Ravi Mehrotra 2 Abstract Matrix metalloproteinases MMPs are a family of zinc-dependent proteinases that are capable of cleaving all extra cellular matrix ECM substrates. Degradation of matrix is a key event in progression invasion and metastasis of potentially malignant and malignant lesions of the head and neck. It might have an important polymorphic association at the promoter regions of several MMPs such as MMP-1 -1607 1G 2G MMP-2 -1306 C T MMP-3 -1171 5A 6A MMP-9 -1562 C T and TIMP-2 -418 G C or C C . Tissue inhibitors of metalloproteinases TIMPs are naturally occurring inhibitors of MMPs which inhibit the activity of MMPs and control the breakdown of ECM. Currently many MMP inhibitors MMPIs are under development for treating different malignancies. Useful markers associated with molecular aggressiveness might have a role in prognostication of malignancies and to better recognize patient groups that need more antagonistic treatment options. Furthermore the introduction of novel prognostic markers may also promote exclusively new treatment possibilities and there is an obvious need to identify markers that could be used as selection criteria for novel therapies. The objective of this review is to discuss the molecular functions and polymorphic association of MMPs and TIMPs and the possible therapeutic aspects of these proteinases in potentially malignant and malignant head and neck lesions. So far no promising drug target therapy has been developed for MMPs in the lesions of this .

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