TAILIEUCHUNG - Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium"

Collection of reports on medical research published in medical journals Wertheim gives you knowledge of medical subjects: Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium . | Open Access Researc h Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium Richard A Stabler Miao He Lisa Dawson Melissa Martin Esmeralda Valiente Craig Corton Trevor D Lawley Mohammed Sebaihia Michael A QuaiT Graham Rose Dale N Gerding Maryse Gibert Michel R Popoff Julian ParkhilT Gordon Dougan and Brendan W Wren Addresses London School of Hygiene and Tropical Medicine Keppel Street London WC1E 7HT UK. Wellcome Trust Genome Campus Hinxton Cambridge CB10 1SA UK. Hines VA Hospital Hines IL 60141 USA. Institut Pasteur rue du Dr Roux 75724 Paris France. Correspondence Brendan W Wren. Email Published 25 September 2009 Genome Biology 2009 10 RI02 doi gb-2009-I0-9-rI02 The electronic version of this article is the complete one and can be found online at http 2009 I0 9 RI02 Received 8 June 2009 Revised 29 June 2009 Accepted 25 September 2009 2009 Stabler et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The continued rise of Clostridium difficile infections worldwide has been accompanied by the rapid emergence of a highly virulent clone designated PCR-ribotype 027. To understand more about the evolution of this virulent clone we made a three-way genomic and phenotypic comparison of an historic non-epidemic 027 C. difficile CD 196 a recent epidemic and hypervirulent 027 R2029I and a previously sequenced PCR-ribotype 0I2 strain 630 . Results Although the genomes are highly conserved the 027 genomes have 234 additional genes compared to 630 which may contribute to the distinct phenotypic differences we observe between these strains relating to motility antibiotic .

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