TAILIEUCHUNG - Báo cáo y học: " The role of recombination in the emergence of a complex and dynamic HIV epidemic"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology cung cấp cho các bạn kiến thức về ngành y đề tài: " The role of recombination in the emergence of a complex and dynamic HIV epidemic. | Zhang et al. Retrovirology 2010 7 25 http content 7 1 25 RETR0VIR0L0GY RESEARCH Open Access The role of recombination in the emergence of a complex and dynamic HIV epidemic 1 3 13 3 Ming Zhang Brian Foley Anne-Kathrin Schultz Jennifer P Macke Ingo Bulla Mario Stanke Burkhard Morgenstern3 Bette Korber1 4 Thomas Leitner1 Abstract Background Inter-subtype recombinants dominate the HIV epidemics in three geographical regions. To better understand the role of HIV recombinants in shaping the current HIV epidemic we here present the results of a large-scale subtyping analysis of 9435 HIV-1 sequences that involve subtypes A B C G F and the epidemiologically important recombinants derived from three continents. Results The circulating recombinant form CRF02_AG common in West Central Africa appears to result from recombination events that occurred early in the divergence between subtypes A and G followed by additional recent recombination events that contribute to the breakpoint pattern defining the current recombinant lineage. This finding also corrects a recent claim that G is a recombinant and a descendant of CRF02 which was suggested to be a pure subtype. The BC and BF recombinants in China and South America respectively are derived from recent recombination between contemporary parental lineages. Shared breakpoints in South America BF recombinants indicate that the HIV-1 epidemics in Argentina and Brazil are not independent. Therefore the contemporary HIV-1 epidemic has recombinant lineages of both ancient and more recent origins. Conclusions Taken together we show that these recombinant lineages which are highly prevalent in the current HIV epidemic are a mixture of ancient and recent recombination. The HIV pandemic is moving towards having increasing complexity and higher prevalence of recombinant forms sometimes existing as families of related forms. We find that the classification of some CRF designations need to be revised as a consequence

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