TAILIEUCHUNG - Báo cáo khoa học: Viral entry mechanisms: human papillomavirus and a long journey from extracellular matrix to the nucleus

Papillomaviruses are epitheliotropic non-enveloped double-stranded DNA viruses, whose replication is strictly dependent on the terminally differenti-ating tissue of the epidermis. They induce self-limiting benign tumors of skin and mucosa, which may progress to malignancy (. cervical carci-noma). Prior to entry into basal cells, virions attach to heparan sulfate moieties of the basement membrane. | MINIREVIEW Viral entry mechanisms human papillomavirus and a long journey from extracellular matrix to the nucleus Martin Sapp and Malgorzata Bienkowska-Haba Department of Microbiology and Immunology Feist Weiller-Cancer Center Louisiana State University Health Sciences Center Shreveport LA USA Keywords attachment capsid protein conformational change endocytosis endosomal escape heparan sulfate papillomavirus PML nuclear body receptor uncoating Correspondence M. Sapp Department of Microbiology and Immunology Feist Weiller-Cancer Center Louisiana State University Health Sciences Center Shreveport LA 71130-3932 USA Fax 1 318 675 5764 Tel 1 318 675 5760 E-mail msapp1@ Papillomaviruses are epitheliotropic non-enveloped double-stranded DNA viruses whose replication is strictly dependent on the terminally differentiating tissue of the epidermis. They induce self-limiting benign tumors of skin and mucosa which may progress to malignancy . cervical carcinoma . Prior to entry into basal cells virions attach to heparan sulfate moieties of the basement membrane. This triggers conformational changes which affect both capsid proteins L1 and L2 and such changes are a prerequisite for interaction with the elusive uptake receptor. These processes are very slow resulting in an uptake half-time of up to 14 h. This minireview summarizes recent advances in our understanding of cell surface events internalization and the subsequent intracellular trafficking of papillomaviruses. Received 16 June 2009 revised 2 September 2009 accepted 17 September 2009 doi Introduction Papillomaviruses PV are epitheliotropic non-envel-oped small DNA viruses with icosahedral symmetry. Their strict dependence on terminally differentiating keratinocytes for completion of the replication cycle initially made the study of entry processes difficult for two reasons. First it was impossible to produce virions until the development of organotypic raft cultures based .

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