TAILIEUCHUNG - Báo cáo y học: "Expression of the C5a receptor (CD88) on granulocytes and monocytes in patients with severe sepsis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Expression of the C5a receptor (CD88) on granulocytes and monocytes in patients with severe sepsis. | Available online http content 6 4 363 Research Expression of the C5a receptor CD88 on granulocytes and monocytes in patients with severe sepsis Mia Furebring1 Lena Douhan Hâkansson2 Per Venge3 Bo Nilsson4 and Jan Sjolin5 1 Resident Department of Medical Sciences Section of Infectious Diseases University Hospital of Uppsala Sweden 2Associate Professor Department of Medical Sciences Section of Clinical Chemistry University Hospital of Uppsala Sweden 3Professor Department of Medical Sciences Section of Clinical Chemistry University Hospital of Uppsala Sweden 4Associate Professor Department of Oncology Radiology and Clinical Immunology University Hospital of Uppsala Sweden 5Associate Professor Department of Medical Sciences Section of Infectious Diseases University Hospital of Uppsala Sweden Correspondence Mia Furebring Received 21 November 2001 Revisions requested 7 March 2002 Revisions received 14 May 2002 Accepted 16 May 2002 Published 13 June 2002 Critical Care 2002 6 363-370 This article is online at http content 6 4 363 2002 Furebring et al. licensee BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract Introduction Treatment of patients with severe sepsis with agents antagonising the effects of C5a has been proposed based on beneficial effects in animal experiments and in vitro studies demonstrating upregulation of the C5a receptor CD88 on granulocytes by endotoxin. Materials and methods CD88 expression on leukocytes from 12 patients with severe sepsis or septic shock was analysed by flow cytometer and serum complement factors C3a and C5b-9 were measured by enzyme immunoassay techniques. Results The granulocyte CD88 expression on day 1 was lowered 36 range 2-59 in comparison with controls 63 range 25-88 P despite complement activation while the monocyte CD88 expression was unchanged. The receptor reduction correlated significantly to the APACHE II score r2 P . The recovery of .

TỪ KHÓA LIÊN QUAN
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.