TAILIEUCHUNG - Báo cáo y học: "Pathogenic Mechanisms Shared between Psoriasis and Cardiovascular Diseas"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Pathogenic Mechanisms Shared between Psoriasis and Cardiovascular Disease. | Int. J. Med. Sci. 2010 7 284 International Journal of Medical Sciences 2010 7 5 284-289 Ivyspring International Publisher. All rights reserved Review Pathogenic Mechanisms Shared between Psoriasis and Cardiovascular Disease Ramin Ghazizadeh1 Hajime Shimizu2 Mamiko Tosa3 Mohammad Ghazizadeh2 1. Academic Dermatology and Skin Cancer Institute East Washington Street Chicago Illinois USA 2. Department of Molecular Pathology Institute of Gerontology Nippon Medical School Kawasaki Japan 3. Department of Plastic and Reconstructive Surgery Musashi-Kosugi Hospital Nippon Medical School Kawasaki Japan H Corresponding author Ramin Ghazizadeh MD Academic Dermatology and Skin Cancer Institute 50 East Washington Street Chicago IL 60602 USA. E-mail rghazi1@ Received Accepted Published Abstract Psoriasis is associated with an increased risk of cardiovascular disease a hallmark of which is atherosclerosis. The objective of this study was to review the pertinent literature and highlight pathogenic mechanisms shared between psoriasis and atherosclerosis in an effort to advocate early therapeutic or preventive measures. We conducted a review of the current literature available from several biomedical search databases focusing on the developmental processes common between psoriasis and atherosclerosis. Our results revealed that the pathogenic mechanisms shared between the two diseases converged onto inflammation phenomenon. Within the lymph nodes antigen-presenting cells activate naive T-cells to increase expression of LFA-1 following which activated T-cells migrate to blood vessel and adhere to endothelium. Extravasation occurs mediated by LFA-1 and ICAM-1 or CD2 and LFA-3 and activated T-cells interact with dendritic cells and macrophages and keratinocytes in psoriasis or smooth muscle cells in atherosclerosis . These cells further secrete chemo-kines and cytokines that contribute to the inflammatory environment resulting in the formation of .

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