TAILIEUCHUNG - Báo cáo y học: "T cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite Controllers"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: T cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite Controllers. | Kamya et al. AIDS Research and Therapy 2011 8 20 http content 8 1 20 AIDS RESEARCH AND THERAPY RESEARCH Open Access T cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite Controllers Philomena Kamya1 2 Christos M Tsoukas1 2 3 Salix Boulet1 2 Jean-Pierre Routy1 2 4 Rejean Thomas5 Pierre Côté6 h I s m I D s r I Dcm I I s r r I4 D r I r r s 6 D I I rv vrl- IX s I I I 7 IV ỉ k r f r h ff lx 7 I I IX .r s ĩ r-8 I I I r m I s 9 Monamed-Racnid Boulassel Bernard Lessard Rupert Kaul Mario Ostrowski Colin Kovacs Cecile L iremblay and Nicole F Bernard1 2 3 Abstract Background Elite controllers EC are a rare subset of HIV infected individuals who control viral load below 50 copies ml of plasma without treatment. Methods Thirty four EC were studied. The slope of CD4 count change was available for 25 of these subjects. We assessed immune activation by measuring the percent of CD38 HLA-DR CD8 T cells in the EC group and comparing it with that in 24 treatment-naive HIV disease progressors and 13 HIV uninfected healthy controls. Results Compared to HIV uninfected subjects EC had higher percentages of CD38 HLA-DR CD8 T cells p that was lower than that observed in progressors p . Fifteen of 25 EC had a slope of CD4 count change that was not significantly different from 0 while 3 had a positive and 7 a negative CD4 count slope. Immune activation did not distinguish EC subsets with stable increasing versus declining CD4 counts. Conclusions Elevated immune activation in ECs is not associated with a faster rate of CD4 decline Keywords HIV infection Elite controllers activation markers CD4 count change Introduction Untreated HIV infection is usually characterized by viral replication and chronic generalized immune activation which is thought to be an important driver of CD4 decline in HIV infection 1-6 . Markers of immune activation such as CD38 can be found on a high proportion of the CD8 T cells in HIV infected .

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