TAILIEUCHUNG - Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis

MicroRNAs (miRNAs) are involved in a plethora of important biological processes, from embryonic development to homeostasis in adult tissues. Recently, miRNAs have emerged as a class of epigenetic regulators of metabolism and energy homeostasis. | ễFEBS Journal A role of miR-27 in the regulation of adipogenesis Qun Lin1 Zhanguo Gao2 Rodolfo M. Alarcon1 Jianping Ye2 and Zhong Yun1 1 Department of Therapeutic Radiology Yale University Schoolof Medicine New Haven CT USA 2 Pennington BiomedicalResearch Center Louisiana State University Baton Rouge LA USA Keywords adipocyte differentiation hypoxia microRNA obesity Correspondence Z. Yun Department of Therapeutic Radiology Yale University Schoolof Medicine 333 Cedar Street HRT-313 New Haven CT 06510 USA Fax 1 203 785 6309 Tel 1 203 737 2183 E-mail Received 24 November 2008 revised 11 February 2009 accepted 13 February 2009 doi MicroRNAs miRNAs are involved in a plethora of important biological processes from embryonic development to homeostasis in adult tissues. Recently miRNAs have emerged as a class of epigenetic regulators of metabolism and energy homeostasis. We have investigated the role of miRNAs in the regulation of adipogenic differentiation. In this article we demonstrate that the miR-27 gene family is downregulated during adipogenic differentiation. Overexpression of miR-27 specifically inhibited adipocyte formation without affecting myogenic differentiation. We also found that expression of miR-27 resulted in blockade of expression of PPARc and C EBPa the two master regulators of adipogenesis. Importantly expression of miR-27 was increased in fat tissue of obese mice and was regulated by hypoxia an important extracellular stress associated with obesity. Our data strongly suggest that miR-27 represents a new class of adipogenic inhibitors and may play a role in the pathological development of obesity. MicroRNAs miRNAs have emerged as an important class of post-transcriptional regulators of metabolism in several cell types including b-cells muscle cells and adipocytes 1 . They appear to be involved in diverse aspects of cellular responses to metabolic demands or stresses from invertebrates to vertebrates.

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