TAILIEUCHUNG - Báo cáo y học: "Comparative analysis reveals signatures of differentiation amid genomic polymorphism in Lake Malawi cichlids"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Comparative analysis reveals signatures of differentiation amid genomic polymorphism in Lake Malawi cichlids. | Open Access Research Comparative analysis reveals signatures of differentiation amid genomic polymorphism in Lake Malawi cichlids Yong-Hwee E Loh Lee S Katz Meryl C Mims Thomas D Kocher Soojin V Yi and J Todd Streelman Addresses School of Biology Petit Institute for Bioengineering and Bioscience Georgia Institute of Technology 315 Ferst Drive Atlanta Georgia 30332 USA. Department of Biology University of Maryland College Park Maryland 20742 USA. Correspondence J Todd Streelman. Email Published 10 July 2008 Genome Biology 2008 9 R113 doi gb-2008-9-7-r1 13 The electronic version of this article is the complete one and can be found online at http 2008 9 7 R113 Received 25 April 2008 Revised 19 June 2008 Accepted 10 July 2008 2008 Loh et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Cichlid fish from East Africa are remarkable for phenotypic and behavioral diversity on a backdrop of genomic similarity. In 2006 the Joint Genome Institute completed low coverage survey sequencing of the genomes of five phenotypically and ecologically diverse Lake Malawi species. We report a computational and comparative analysis of these data that provides insight into the mechanisms that make closely related species different from one another. Results We produced assemblies for the five species ranging in aggregate length from 68 to 79 megabase pairs identified putative orthologs for more than 12 000 human genes and predicted more than 32 000 cross-species single nucleotide polymorphisms SNPs . Nucleotide diversity was lower than that found among laboratory strains of the zebrafish. We collected around 36 000 genotypes to validate a subset of SNPs within and .

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