TAILIEUCHUNG - Báo cáo y học: "Sense-antisense pairs in mammals: functional and evolutionary considerations"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Sense-antisense pairs in mammals: functional and evolutionary considerations. | Open Access Research Sense-antisense pairs in mammals functional and evolutionary considerations Pedro AF Galante Daniel O Vidal Jorge E de Souza Anamaria A Camargo and Sandro J de Souza Addresses Ludwig Institute for Cancer Research São Paulo Branch Hospital Alemão Oswaldo Cruz Rua João Juliao 245 1 andar São Paulo SP 01323-903 Brazil. Department Of Biochemistry University of São Paulo Av. Prof. Lineu Prestes 748 - sala 351 São Paulo SP 05508-900 Brazil. Correspondence Sandro J de Souza. Email sandro@ Published 19 March 2007 Genome Biology 2007 8 R40 doi 186 gb-2007-8-3-r40 The electronic version of this article is the complete one and can be found online at http 2007 8 3 R40 Received 3 May 2006 Revised 4 September 2006 Accepted 19 March 2007 2007 Galante et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background A significant number of genes in mammalian genomes are being found to have natural antisense transcripts NATs . These sense-antisense S-AS pairs are believed to be involved in several cellular phenomena. Results Here we generated a catalog of S-AS pairs occurring in the human and mouse genomes by analyzing different sources of expressed sequences available in the public domain plus 122 massively parallel signature sequencing MPSS libraries from a variety of human and mouse tissues. Using this dataset of almost 20 000 S-AS pairs in both genomes we investigated in a computational and experimental way several putative roles that have been assigned to NATs including gene expression regulation. Furthermore these global analyses allowed us to better dissect and propose new roles for NATs. Surprisingly we found that a significant fraction of NATs are artifacts .

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