TAILIEUCHUNG - Báo cáo y học: " Koala retrovirus: a genome invasion in real time"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Koala retrovirus: a genome invasion in real time. | Minireview Koala retrovirus a genome invasion in real time Jonathan P Stoye Address Division of Virology National Institute for Medical Research The Ridgeway Mill Hill London NW7 1AA UK. Email jstoye@ Published 21 November 2006 Genome Biology 2006 7 241 doi gb-2006-7-ll-24l The electronic version of this article is the complete one and can be found online at http 2006 7 ll 24l 2006 BioMed Central Ltd Abstract Koalas are currently undergoing a wave of germline infections by the retrovirus KoRV. Study of this phenomenon not only provides an opportunity for understanding the processes regulating retrovirus endogenization but may also be essential to preventing the extinction of the species. The genomes of all higher organisms are littered with the remnants of past retroviral infections some dating back many tens of millions of years. The unique replication cycle of retroviruses involving the integration of viral genetic information into host-cell DNA as a provirus allows the formation of a permanent association between the virus and the infected cell. If the infected cell is a germ cell then that genetic association can persist for many generations with the provirus forming part of the genome of every cell in progeny. Until now we have never had the opportunity of observing or studying such genomic colonization as it takes place. Enter the koala - an Australian icon and a potentially endangered species. A recent paper in Nature by Tarlington and colleagues 1 provides evidence that koalas are in the midst of a germline invasion by the koala retrovirus KoRV . They show that KoRV is present at variable copy number in the germline of all koalas found in Queensland but that animals from some areas of southern Australia lack the provirus. Most notably KoRV appears completely absent from koalas on Kangaroo Island off the coast of South Australia. This island was stocked with koalas in the early part of the twentieth century and has .

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