TAILIEUCHUNG - Book: Biomedical Engineering_1

Biomedical Engineering can be seen as a mix of Medicine, Engineering and Science. In fact, this is a natural connection, as the most complicated engineering masterpiece is the human body. And it is exactly to help our “body machine” that Biomedical Engineering has its niche. This book brings the state-of-the-art of some of the most important current research related to Biomedical Engineering. | 1 Microelectronic Biosensors Materials and Devices David P. Klemer MD PhD University of Wisconsin-Milwaukee Milwaukee Wisconsin . 1. Introduction The advent of novel materials for electronics optoelectronics and nanoelectronics holds the promise for new microelectronic device designs and applications across all fields of science and technology. Furthermore the increasing sophistication of fabrication processes and techniques used in the semiconductor industry has resulted in the ability to produce circuits of greater complexity at remarkably reduced costs a trend which has been continuing over the past half-century. Application of progress made in the microelectronics industry to the biomedical and biotechnology fields is a research area rich in possibilities given the rapid parallel growth in both microelectronics and biotechnology. It is an unfortunate fact that new advances in biotechnology and biomedical engineering have historically tended to increase the costs of medicine and healthcare Patel Rushefsky 2006 . For example a computed tomography CT scan is typically more expensive than traditional digital or plain film x-ray imaging and a magnetic resonance MR scan is typically more expensive than a CT scan. Incorporation of the principles and techniques used in the microelectronics field has the potential for reversing this trend. Based on a batchfabrication approach mature processing techniques used in the semiconductor industry have the potential for dramatically reducing the cost of manufacture for diagnostic devices used for the detection treatment and management of disease. It is thus of critical importance to develop a knowledge base which spans the interdisciplinary boundary between microelectronics and biotechnology. In this chapter we will review the materials and devices which can serve to bridge the interdisciplinary boundary between microelectronics and biomedicine and we will discuss some of the resulting novel biosensor designs which have .

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