TAILIEUCHUNG - Báo cáo khoa học: The role of prohibitin in cell signaling

Prohibitin-1 (PHB, also known as PHB1), a member of the Band-7 family of proteins, is highly conserved evolutionarily, widely expressed, and pres-ent in different cellular compartments. Genetic studies with different organ-ism models have provided strong evidence for an important biological role of PHB in mitochondrial function, cell proliferation, and development. | ỊFEBS Journal REVIEW ARTICLE The role of prohibitin in cell signaling Suresh Mishra1 2 Sudharsana R. Ande1 and B. L. Gregoire Nyomba1 2 1 Department of InternalMedicine University of Manitoba Winnipeg Manitoba Canada 2 Department of Physiology University of Manitoba Winnipeg Manitoba Canada Keywords post-translationalmodification protein kinase B Akt protein-protein interaction Raf-1 receptor tyrosine kinase Correspondence S. Mishra Diabetes Research Group University of Manitoba 715 McDermot Avenue Room 843 Winnipeg Manitoba Canada R3E 3P4 Fax 1 204 789 3940 Tel 1 204 977 5629 E-mail Mishra@ Received 19 May 2010 revised 4 July 2010 accepted 5 August 2010 doi Prohibitin-1 PHB also known as PHB1 a member of the Band-7 family of proteins is highly conserved evolutionarily widely expressed and present in different cellular compartments. Genetic studies with different organism models have provided strong evidence for an important biological role of PHB in mitochondrial function cell proliferation and development. Recent discoveries regarding the involvement of PHB in phophatidylinosi-tol-3-kinase PI3K protein kinase B Akt and transforming growth factor-b TGF-P signal transducers and activators of transcription signaling pathways and earlier reports on the interaction of PHB with Raf and its critical role in Ras mitogen-activated protein kinase MAPK extracellular signal-regulated kinase ERK signaling opened up the possibility that PHB has functions outside of the mitochondria extramitochondrial and may be a multifunctional protein. The PI3K Akt and Ras MAPK ERK signaling cascades are versatile signaling processes that diverge from the same receptor tyrosine kinase root and are involved in cell metabolism proliferation and development. Here we review the emerging role of PHB and its post-translational modifications in signal transduction pathways especially in PI3K Akt and Ras MAPK ERK signaling. A recent discovery of .

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