TAILIEUCHUNG - Cell Biology and Cancer under a contract from the National Institutes of Health

Because of accessibility and the risk of involvement of bony struc- tures, treatment with radiotherapy can lead to radionecrosis of the mandible or maxilla. Moreover, oral cavity squamous cell carcino- mas may be less sensitive to chemotherapy and radiation, relative to oropharyngeal or laryngeal cancers. Thus, primary treatment for most tumors is surgical. Positive surgical margins, multiple involved lymph nodes, and/or extracapsular tumor extension call for consid- eration of postoperative chemoradiotherapy, to improve local dis- ease control | Cell Biology and Cancer under a contract from the National Institutes of Health National Cancer Institute BSCS 5415 Mark Dabling Boulevard Colorado Springs Colorado 80918 VDEOMSCCVERT Videodiscovery Inc. 1700 Westlake Avenue North Suite 600 Seattle Washington 98109 BSCS Development Team Joseph D. McInerney Co-Principal Investigator Lynda B. Micikas Co-Project Director April L. Gardner Visiting Scholar Diane Gionfriddo Research Assistant Joy L. Hainley Research Assistant Judy L. Rasmussen Senior Executive Assistant Barbara C. Resch Editor Janie Mefford Shaklee Evaluator Lydia E. Walsh Research Assistant Videodiscovery Inc. Development Team D. Joseph Clark Co-Principal Investigator Shaun Taylor Co-Project Director Michael Bade Multimedia Producer Dave Christiansen Animator Greg Humes Assistant Multimedia Producer Lucy Flynn Zucotti Photo Researcher Advisory Committee Ken Andrews Colorado College Colorado Springs Colorado Kenneth Bingman Shawnee Mission West High School Shawnee Mission Kansas Julian Davies University of British Columbia Vancouver BC Canada Lynn B. Jorde Eccles Institute of Human Genetics Salt Lake City Utah Elmer Kellmann Parkway Central High School Chesterfield Missouri Mark A. Rothstein University of Houston Law Center Houston Texas Carl W. Pierce Consultant Hermann Missouri Kelly A. Weiler Garfield Heights High School Garfield Heights Ohio Raymond L. White Huntsman Cancer Institute Salt Lake City Utah Aimee L. Wonderlick Northwestern University Medical School Chicago Illinois Writing Team Mary Ann Cutter University of Colorado Colorado Springs Jenny Sigstedt Consultant Steamboat Springs Colorado Vickie Venne Huntsman Cancer Institute Salt Lake City Utah Artists Dan Anderson Kevin Andrews Cover Design Karen Cook NIH Medical Arts and Photography Branch Design and Layout Angela Greenwalt Finer Points Productions BSCS Administrative Staff Timothy H. Goldsmith Chairman Board of Directors Joseph D. McInerney Director Michael J. Dougherty Associate .

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