TAILIEUCHUNG - Chapter 061. Disorders of Granulocytes and Monocytes (Part 7)

Miscellaneous Metabolic disorders—ketoacidosis, acute renal failure, eclampsia, acute poisoning Drugs—lithium Other—metastatic carcinoma, acute hemorrhage or hemolysis Abnormal Neutrophil Function Inherited and acquired abnormalities of phagocyte function are listed in Table 61-3. The resulting diseases are best considered in terms of the functional defects of adherence, chemotaxis, and microbicidal activity. The distinguishing features of the important inherited disorders of phagocyte function are shown in Table 61-4. Table 61-3 Types of Granulocyte and Monocyte Disorders Cause of Indicated Dysfunction Function Drug-Induced Acquired Inherited Adherenceaggregation Aspirin, colchicine, alcohol, state, Neonatal Leukocyte adhesion deficiency types 1 and 2 glucocorticoids, ibuprofen, piroxicam hemodialysis Deformability . | Chapter 061. Disorders of Granulocytes and Monocytes Part 7 Miscellaneous Metabolic disorders ketoacidosis acute renal failure eclampsia acute poisoning Drugs lithium Other metastatic carcinoma acute hemorrhage or hemolysis Abnormal Neutrophil Function Inherited and acquired abnormalities of phagocyte function are listed in Table 61-3. The resulting diseases are best considered in terms of the functional defects of adherence chemotaxis and microbicidal activity. The distinguishing features of the important inherited disorders of phagocyte function are shown in Table 61-4. Table 61-3 Types of Granulocyte and Monocyte Disorders Cause of Indicated Dysfunction Function Drug-Induced Acquired Inherited Adherence- aggregation Aspirin colchicine alcohol glucocorticoids ibuprofen piroxicam Neonatal state hemodialysis Leukocyte adhesion deficiency types 1 and 2 Deformability Leukemia neonatal state diabetes mellitus immature neutrophils Chemokinesis- Glucocorticoids high dose auranofin Thermal injury Chediak- Higashi syndrome chemotaxis colchicine weak effect phenylbutazone naproxen indomethacin interleukin 2 malignancy malnutrition periodontal disease neonatal state systemic lupus erythematosus rheumatoid arthritis diabetes mellitus sepsis influenza virus infection herpes simplex virus infection acrodermatitis enteropathica AIDS neutrophil-specific granule deficiency hyper IgE- recurrent infection Job s syndrome in some patients Down syndrome a-mannosidase deficiency severe combined immunodeficiency Wiskott-Aldrich syndrome Microbicidal activity Colchicine cyclophosphamide glucocorticoids high Leukemia aplastic anemia certain Chédiak- Higashi syndrome .

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