TAILIEUCHUNG - Chapter 061. Disorders of Granulocytes and Monocytes (Part 4)

Neutrophil travel through the pulmonary capillaries is dependent on neutrophil deformability. Neutrophil rigidity (., caused by C5a) enhances pulmonary trapping and response to pulmonary pathogens in a way that is not so dependent on cell-surface receptors. Intraalveolar chemotactic factors, such as those caused by certain bacteria (., Streptococcus pneumoniae) lead to diapedesis of neutrophils from the pulmonary capillaries into the alveolar space. Neutrophil interaction with the endothelium of the systemic postcapillary venules is dependent on molecules of attachment. The neutrophil "rolls" along the endothelium using selectins: neutrophil CD15s (sialyl-Lewisx) binds to CD62E (Eselectin) and CD62P (P-selectin) on endothelial cells; CD62L. | Chapter 061. Disorders of Granulocytes and Monocytes Part 4 Figure 61-8 Neutrophil travel through the pulmonary capillaries is dependent on neutrophil deformability. Neutrophil rigidity . caused by C5a enhances pulmonary trapping and response to pulmonary pathogens in a way that is not so dependent on cell-surface receptors. Intraalveolar chemotactic factors such as those caused by certain bacteria . Streptococcus pneumoniae lead to diapedesis of neutrophils from the pulmonary capillaries into the alveolar space. Neutrophil interaction with the endothelium of the systemic postcapillary venules is dependent on molecules of attachment. The neutrophil rolls along the endothelium using selectins neutrophil CD15s sialyl-Lewisx binds to CD62E Eselectin and CD62P P-selectin on endothelial cells CD62L L-selectin on neutrophils binds to CD34 and other molecules . GlyCAM-1 expressed on endothelium. Chemokines or other activation factors stimulate integrin-mediated tight adhesion CD11a CD18 LFA-1 and CD11b CD18 Mac-1 CR3 bind to CD54 ICAM-1 and CD102 ICAM-2 on the endothelium. Diapedesis occurs between endothelial cells CD31 PECAM-1 expressed by the emigrating neutrophil interacts with CD31 expressed at the endothelial cell-cell junction On cell stimulation L-selectin is shed from neutrophils and E-selectin increases in the blood presumably because it is shed from endothelial cells receptors for chemoattractants and opsonins are mobilized and the phagocytes orient toward the chemoattractant source in the extravascular space increase their motile activity chemokinesis and migrate directionally chemotaxis into tissues. The process of migration into tissues is called diapedesis and involves the crawling of neutrophils between postcapillary endothelial cells that open junctions between adjacent cells to permit leukocyte passage. Diapedesis involves platelet endothelial cell adhesion molecule PECAM 1 CD31 which is expressed on both the emigrating leukocyte and the .

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