TAILIEUCHUNG - Báo cáo y học: "Thoracic epidural anesthesia reverses sepsis-induced hepatic hyperperfusion and reduces leukocyte adhesion in septic rats"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Thoracic epidural anesthesia reverses sepsis-induced hepatic hyperperfusion and reduces leukocyte adhesion in septic rats. | Available online http content 13 4 R116 Research Thoracic epidural anesthesia reverses sepsis-induced hepatic hyperperfusion and reduces leukocyte adhesion in septic rats Hendrik Freise1 Fritz Daudel2 Christina Grosserichter1 Stefan Lauer1 Juergen Hinkelmann1 Hugo K Van Aken1 Andreas W Sielenkaemper3 Martin Westphal1 and Lars G Fischer1 1 Department of Anesthesiology and Intensive Care University Hospital of Muenster Albert-Schweitzer-Strasse 33 48149 Muenster Germany 2Department of Intensive Care Medicine Inselspital University of Bern Freiburgstrasse 3010 Bern Switzerland department of Anesthesiology and Intensive Care Medicine St. Theresien-Hospital Saarbrucken RheinstraBe 2 66113 Saarbrucken Germany Corresponding author Hendrik Freise freiseh@ Received 13 Mar 2009 Revisions requested 5 May 2009 Revisions received 26 May 2009 Accepted 13 Jul 2009 Published 13 Jul 2009 Critical Care 2009 13 R11 6 doi cc7965 This article is online at http content 13 4 R116 2009 Freise et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Liver dysfunction is a common feature of severe sepsis and is associated with a poor outcome. Both liver perfusion and hepatic inflammatory response in sepsis might be affected by sympathetic nerve activity. However the effects of thoracic epidural anesthesia TEA which is associated with regional sympathetic block on septic liver injury are unknown. Therefore we investigated hepatic microcirculation and inflammatory response during TEA in septic rats. Methods Forty-five male Sprague-Dawley-rats were instrumented with thoracic epidural catheters and randomized to receive a sham procedure Sham cecal ligation and puncture CLP .

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