TAILIEUCHUNG - Nature Reviews Molecular Cell biology

The faithful and complete replication of chromosomes is essential to maintain genetic stability and prevent the accumulation of cancer-promoting mutations. Replication forks are vulnerable to stalling or collapse as they encounter obstacles on the DNA template, which can be unrepaired DNA damage, DNA-bound proteins or secondary structures. Similarly, chemical agents like hydroxyurea and aphidicolin inhibit replication elongation, leading to fork stalling or collapse. | PROGRESS Pathways of mammalian replication fork restart Eva Petermann and Thomas Helleday Abstract Single-molecule analyses of DNA replication have greatly advanced our understanding of mammalian replication restart. Several proteins that are not part of the core replication machinery promote the efficient restart of replication forks that have been stalled by replication inhibitors suggesting that bona fide fork restart pathways exist in mammalian cells. Different models of replication fork restart can be envisaged based on the involvement of DNA helicases nucleases homologous recombination factors and the importance of DNA double-strand break formation. The faithful and complete replication of chromosomes is essential to maintain genetic stability and prevent the accumulation of cancer-promoting mutations. Replication forks are vulnerable to stalling or collapse as they encounter obstacles on the DNA template which can be unrepaired DNA damage DNA-bound proteins or secondary structures. Similarly chemical agents like hydroxyurea and aphidicolin inhibit replication elongation leading to fork stalling or collapse. A stalled replication fork is arrested but is capable of resuming replication replication fork restart once the inhibition is removed whereas a collapsed fork has become inactivated through dissociation of the replication machinery or the generation of DNA double-strand breaks DSBs . In eukaryotic cells fork-associated DSBs are generated by the structurespecific endonuclease complex of methyl methanesulphonate MMS and ultravioletsensitive 81 MUS81 and essential meiotic endonuclease 1 EME1 1. After the removal of replication inhibitors such as aphidicolin and hydroxyurea replication resumes by mechanisms that have been poorly understood in mammalian cells. More is known about replication restart in Escherichia coli in which stalled or collapsed forks are reactivated by recombination-dependent or recombinationindependent pathways depending on their .

• Môi trường
• DNA double
• DNA helicases
• nucleases
• DNA replication
• replication inhibitors
• replication origin
• BMC Bioinformatics
• Single stranded DNA binding proteins
• Double stranded DNA binding proteins
• Binding specificity
• Protein sequence
• Cervical cancer
• DNA double strand break repair
• Ionizing radiation
• Immediate early response gene 5
• Dose independent manner
• ADP Ribose
• BMC Cancer
• DNA double strand breaks
• Single nucleotide polymorphisms
• Individual’s susceptibility
• Single locus analysis
• Genome Biology
• Double strand breaks
• Machine learning
• Multiple sources
• Including radiation
• Abnormal chromosomal
• Mesenchymal stem cells
• DNA damage response
• Replicative senescence
• oxidative stress
• BMC Genomics
• DNA double stranded breaks
• Break end type
• DNA end resection
• Etoposide treatment
• Topoisomerase II
• Double strand break repair
• Lung cancer
• Nucleotide excision repair pathways
• X ray irradiation
• DNA molecules
• Computational biology
• Physical mapping
• Double digest problem
• 3D chromosomal structure
• Intergenic region
• Saccharomyces cerevisiae
• Genome editing
• Homology directed repair
• Non homologous end joining
• Human induced pluripotent stem cells
• báo cáo khoa học
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• công trình nghiên cứu về y học
• tài liệu về y học
• cách trình bày báo cáo
• Double Helical Structure
• Plasticity in DNA Structure
• DNA Synthesis
• Sources and Additional Readings
• Number of Genes
• Bacterial Chromosomes
• BMC Biotechnology
• Single crossover
• Human CCR5 gene
• DNA fragments
• BMC Plant Biology
• Comet assay
• DNA damage
• Gene expression
• RAD21 cohesin plays
• Ataxia–telangiectasia mutated
• Reactive oxygen species
• Superoxide dismutase
• Breast carcinoma
• DNA damage repair
• DNA double strand break repair disorder
• Ionising radiation sensitivity
• MRN complex
• ImageJ plugin
• Automated analysis
• Radiation biology
• Journal of Chemistry
• DNA herbicide interaction
• 2 4 dichlorophenoxyacetic acid
• Pencil graphite electrode
• Voltammetric analysis
• Electrochemical characterization
• Microscopic characterization
• Gamma ray irradiation
• Bacillus subtilis spores
• DNA repair
• DNA protection
• Homologous recombination
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• tài liệu báo cáo khoa học
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