TAILIEUCHUNG - Báo cáo y học: " Scale-free flow of life: on the biology, economics, and physics of the cell"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: "Scale-free flow of life: on the biology, economics, and physics of the cell | Theoretical Biology and Medical Modelling BioMed Central Open Access Review Scale-free flow of life on the biology economics and physics of the cell Alexei Kurakin Address Department of Pathology Beth Israel Deaconess Medical Center and Harvard Medical School Boston MA 02215 USA Email Alexei Kurakin - akurakin@ Published 5 May 2009 Received 15 April 2009 Theoretical Biology and Medical Modelling 2009 6 6 doi 1742-4682-6-6 Accepted 5 May 2009 This article is available from http content 6 1 6 2009 Kurakin licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The present work is intended to demonstrate that most of the paradoxes controversies and contradictions accumulated in molecular and cell biology over many years of research can be readily resolved if the cell and living systems in general are re-interpreted within an alternative paradigm of biological organization that is based on the concepts and empirical laws of nonequilibrium thermodynamics. In addition to resolving paradoxes and controversies the proposed re-conceptualization of the cell and biological organization reveals hitherto unappreciated connections among many seemingly disparate phenomena and observations and provides new and powerful insights into the universal principles governing the emergence and organizational dynamics of living systems on each and every scale of biological organizational hierarchy from proteins and cells to economies and ecologies. Background The introduction of proteomics technologies has opened unprecedented opportunities to compile comprehensive parts lists for various macromolecular complexes organelles and whole cells. In a typical proteomics experiment an organelle or a macromolecular

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