TAILIEUCHUNG - Báo cáo khoa học: MicroRNAs and cardiovascular diseases

MicroRNAs (miRNAs) are a class of small noncoding RNAs that have gained status as important regulators of gene expression. Recent studies have demonstrated that miRNAs are aberrantly expressed in the cardiovas-cular system under some pathological conditions. | IFEBS Journal MINIREVIEW MicroRNAs and cardiovascular diseases Koh Ono1 2 Yasuhide Kuwabara1 and Jiahuai Han2 1 Department of Cardiovascular Medicine Graduate Schoolof Medicine Kyoto University Japan 2 Department of Immunology and MicrobialScience The Scripps Research Institute La Jolla CA USA Keywords angiogenesis arrhythmia cardiac development fibrosis heart failure hypertrophy metabolic syndrome myocardialinfarction Correspondence K. Ono Department of Cardiovascular Medicine Kyoto University 54 Shogoin-Kawaharacho Sakyo-ku Kyoto 606-8507 Japan Fax 81 75 751 3203 Tel 81 75 751 3190 E-mail kohono@ MicroRNAs miRNAs are a class of small noncoding RNAs that have gained status as important regulators of gene expression. Recent studies have demonstrated that miRNAs are aberrantly expressed in the cardiovascular system under some pathological conditions. Gain- and loss-of-func-tion studies using in vitro and in vivo models have revealed distinct roles for specific miRNAs in cardiovascular development and physiological function. The implications of miRNAs in cardiovascular disease have recently been recognized representing the most rapidly evolving research field. In the present minireview the current relevant findings on the role of miRNAs in cardiac diseases are updated and the target genes of these miRNAs are summarized. Received 11 November 2010 revised 4 February 2011 accepted 1 March 2011 doi Introduction MicroRNAs miRNAs are endogenous singlestranded small approximately 22 nucleotides in length noncoding RNAs. miRNAs are generally regarded as negative regulators of gene expression by inhibiting translation and or promoting mRNA degradation by base pairing to complementary sequences within the 3 UTR region of protein-coding mRNA transcripts 1-3 . However recent studies have suggested that miR-binding sites are also located in 5 UTRs or ORFs and the mechanism s of miR-mediated regulation from these sites has not .

• Báo cáo khoa học
• Scientific reports
• scientific research
• Structural biochemistry
• MicroRNAs
• cardiovascular disease
• immune system
• collection of scientific reports
• industry reports philosophy of history reports
• reports in literature
• a scientific b shirt
• presentation of scientific reports
• reports on literature
• philosophy statement
• documents
• studies English language and English language communication and English language commercial
• progress reports at scientific collections
• agronomic reports
• reports in physics
• biology reports
• thematic biological
• induced geometry
• mathematical topics
• quantum mechanics
• physics
• reporting mathematics
• physics reports
• livestock reports
• physical reports
• research physicist
• specializing in physics
• mathematical statements
• mathematical equations
• English pronunciation
• presentation report
• agricultural reports
• technical crops
• bio technology
• English reports
• presentation reports
• mathematical knowledge
• reports of mathematics
• represented
• Wilf on packing distinct
• Tur´n density
• mathematical works
• patterns in a permutation
• statements and documents scientific reports
• reports agronomy
• biotechnology
• plants Vietnam
• specialized biological
• microbiological methods
• presenting the report
• anti bacterial properties of shrimp
• energy exchange
• engineering chicken
• Path counting
• random matrix theory
• Even circuits
• prescribed clockwise parity
• Correspondence between
• algorithmic characterizations
• Finding Induced Acyclic
• Random Digraphs
• Nonexistence results
• Hadamard like matrices
• Voltage Graphs
• Group Presentations
• Cages mathematical knowledge
• Dominance Order
• Graphical Partitions
• On the functions
• values in [α(G
• Box With Translates
• Two Given Rectangular Brick
• On the q analogue
• the sum of cubes