TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 185

Pharmaceutical Substances Syntheses, Patents, Applications - Part 185. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers. | Rosoxacin R 1841 Reference s a Cantello . et al. J. Med. Chem. JMCMAR 37 3977-3985 1994 . Cantello . et al. Bioorg. Med. Chem. Lett. BMCLE8 4 1 29. 1994 . EP 306 228 Beecham appl. GB-prior. . b Cantello . et al. J. Chem. Soc. Perkin Trans. 1 JCPRB4 1994 3319. Heath . et al. J. Chem. Technol. Biotechnol. JCTBED 68 3 324-330 1997 . WO 9 310 254 SmithKline Beecham appl. GB-prior. . c WO 9 923 095 SmithKline Beecham appl. GB-prior. . d WO 9 837 073 SmithKline Beecham appl. GB-prior. . maleate salt and other derivatives WO9405 659 SmithKline Beecham appl. GB-prior. . treatment of diabetes with insulin and rosiglitazone WO 9 837 073 SmithKline Beecham appl. GB-prior. . Formulation s tabl. 2 mg 4 mg 8 mg Trade Name s USA Avandia SmithKline Beecham 1999 Rosoxacin Acrosoxacin ATC J01MB01 Use antibiotic RN 40034-42-2 MF C17H14N2O3 MW EINECS 254-758-4 CN 1 -ethyl-1 4-dihydro-4-oxo-7- 4-pyridinyl -3-quinolinecarboxylic acid sodium salt RN 40035-08-3 MF C17H13N2NaO3 MW CH3COONH4 CHjCOOH ammonium acetate dimethyl 1 4-dihydro-4- 3-nitrophenyl -3 5-pyridinedicarboxylate I 0 A CH C O 3 HC 3-nitro- methyl benzoldehyde ocetylene- carboxylate 2. KOH 3. Cu2O HCI 3. copper I oxide Fe CHjCOOH 4- 3-nitraphenyl - pyridine 4- 3-ominophenyl -pyridine II diethyl ethoxymethylene-malonate l3 CH3 O diethyl 3- 4-pyridyl -anilinomethylene molonate 1842 R Roxatidine acetate ethyl 4-oxo-7- 4-pyridyl - 1 4-dihydroquinotine-3-curboxylate III ch3 O O 3 O O ethyl 1 -ethyl-4-oxo-7 4 pyridyl -1 4-díhydroquinoline-3-carboxylate IV KOH H2O IV -------------- Reference s US 3 753 993 Sterling Drug prior. . US 3 907 808 Sterling Drug prior. . US 3 922 278 Sterling Drug prior. . alternative synthesis US 4 107 167 Sterling Drug prior. . Formulation s cps. 150 mg Trade Name s

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