TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 218

Pharmaceutical Substances Syntheses, Patents, Applications - Part 218. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers. | Vincamine V 2171 combination with glucose 1-phosphate BE 874 154 E. Corvi Mora appl. . quaternary ammonium salts DE 1 244 794 Richter Gedeon appl. H-prior. . Formulation s amp. 15 mg 1 ml 20 mg cps. 20 mg 60 mg Trade Name s F Cervoxan SmithKline Beecham I Eburnal Chiesi Scleramin Ibim Tensiplex Francia Farm. Vincamine atc C04AX07 Use vasodilator antihypertensive cerebrotonic RN 1617-90-9 MF C21H26N2O3 MW EINECS 216-576-3 LD 0 mg kg M . 460 mg kg M . 1200 mg kg R . - CN 3a 14ß 16a -14 15-dihydro-14-hydroxyebumamenine-14-carboxylic acid methyl ester by extraction of pulverized and NHj-solution treated plant material of Vinca minor L. myrtle with toluene and column chromatographic separation of numerous c. 30 biogenetic related by-olkaloids indole olkaloids b partial synthesis Omnium process - -tabersanine from Voacanga grains H2 PtO or Pt C or Pd C ---------------------- - -vincadifformine Cl zp so-OH 3-chloroper- benzoic acid 3-chloroper- benzoic acid - -vincadifformine 9 oxide I -3-hydroxy-3-methoxy- carbonyl-1 2-didehydro- aspidospermidine 9-oxide II c6h5 3p CH-jCOOH II --------------- triphenyl- phasphine opovincamine - -14 epivincamine III -Vmcamine 2172 V Vincamine in Ag2C0j celite or Pt Rh -Vincomine in the product mixture total synthesis Richter Gedeon synthesis 0 CH3 0 NoOCnHe 0 -CH diethyl 2-ethyl-2- 3-chloropropyl - N 0H HOOC COOH diethyl ethyl-malonate 1 -bromo-3-chforopropane malonate 2-ethyl-2- 3-hydroxypropyl -molonic ocid IV 3-ethyl-tetrohydro-2H-pyran-2-one 1. POCI3 2. HCIO4 1 -ethyl-1 2 3 4 6 7-hexahydroindolo 2 3-o -quinolizin-5-ium perchlorote VII CI04 -epivincomine DC -vincomine X Vincamine V 2173 Ag2CO3 celite or Pt Rh DC ------------------------- X racemate resolution with -tartaric acid or -O O -dibenzoyltartaric acid or -camphorsulfonic acid -------------------------------------- -Vincamine in the mixture of racemates c2j Roussel-Uclof synthesis 0HC x CH3 butyraldehyde TosOH ------- 3 0 2.

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