TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 51

Pharmaceutical Substances Syntheses, Patents, Applications - Part 51. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | F Clidinium bromide c 501 in KCN ì Ỉ potassium cyanide - 2. H2 Pd-C IV -------------- II 1. aluminum . chloride N-chloro-succinimide IV itftfriïîfôfrWt fiTiiii Referenced a Juby . et al. J. Med. Chem. JMCMAR 15 1297 1972 . alternative synthesis described b DOS 2004038 Bristol-Myers appl. usA-prior. . US 3 565 943 Bristol-Myers 1971 prior. . I US 3 663 627 Bristol-Myers prior. . alternative synthesis I DOS 2 330 856 Takeda appl. J-prior. . Formulatian s tabl. 15 mg Trade Name s J Britai Bristol-Banyu Indanol Takeda Clidinium bromide ATC A03CA02 Use anticholinergic i I RN 3485-62-9 MF C22H26BrNO3 MW EINECS 222-471-3 LDJ0 16 mg kg M . 492 mg kg M . I 26 mg kg dog . P CN 3- hydroxydiphenylacetyl oxy -l-methyl-l-azoniabicyclo octanebromide methyl iso- ethyl bromo- nicotinote acetate 1. K 2. HCI 3. KOH ----- H2 pto 3-0X0-quinuclidine 3-hydroxy-quinuclidine II 502 c Clindamycin chloride HjC Br methyl bromide Clidinium bromide Reference s US 2 648 667 Hoffmann-La Roche 1955 prior. 1951 . Formulation s drg. mg Trade Name s D Librax Roche -comb. with chlorodiazepoxide wfm F Librax Roche -comb. with chlorodiazepoxide GB Libraxin Roche -comb. with chlorodiazepoxide wfm I Librax Roche -comb. with chi orodi azepoxide USA Librax Roche -comb. with chi orodi azepoxide Clindamycin ATC D10AF01 G01AA10 JO1FF01 Use antibiotic RN 18323-44-9 MF CI8H33C1N2O5S MW EINECS 242-209-1 LD50 2618 mg kg R . CN - -mcthyl 7-chloro-6 7 8-trideoxy-6- l-methyl-4-propyl-2-pyrrolidinyl carbonyl amino -l-thio-L-t ỉreơ-a-D-gw íỉcrơ-octopyranoside monohydrochloride RN 21462-39-5 MF C18H33C1N2O5S HC1 MW EINECS 244-398-6 LD5 245 mg kg M . 2539 mg kg M . 2193 mg kg R . lincomycin Reference s US 3 496 163. DE 1 795 740 US 3 418 414 Upjohn appl. . US 3 475 407 Upjohn appl. . US 3 509 127 Upjohn

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