TAILIEUCHUNG - Arachidonic acid in health and disease with focus on hypertension and diabetes mellitus: A review

Arachidonic acid (AA 20:4n-6) is an essential component of cell membranes and modulates cell membrane fluidity. AA is metabolized by cyclo-oxygenase (COX), lipoxygenase (LOX) and cytochrome P450 enzymes to form several metabolites that have important biological actions. Of all the actions, role of AA in the regulation of blood pressure and its ability to prevent both type 1 and type 2 diabetes mellitus seems to be interesting. Studies showed that AA and its metabolites especially, lipoxin A4 (LXA4) and epoxyeicosatrienoic acids (EETs), potent anti-inflammatory metabolites, have a crucial role in the pathobiology of hypertension and diabetes mellitus. AA, LXA4 and EETs regulate smooth muscle function and proliferation, voltage gated ion channels, cell membrane fluidity, membrane receptors, G-coupled receptors, PPARs, free radical generation, nitric oxide formation, inflammation, and immune responses that, in turn, participate in the regulation blood pressure and pathogenesis of diabetes mellitus. In this review, role of AA and its metabolites LXA4 and EETs in the pathobiology of hypertension, pre-eclampsia and diabetes mellitus are discussed. Based on several lines of evidences, it is proposed that a combination of aspirin and AA could be of benefit in the prevention and management of hypertension, pre-eclampsia and diabetes mellitus. | Arachidonic acid in health and disease with focus on hypertension and diabetes mellitus: A review

• Y khoa - Dược
• Arachidonic acid
• Lipoxin A4
• Pre eclampsia
• Diabetes mellitus
• Hypertension and diabetes mellitus
• Diabetes mellitus
• Delta desaturases
• Lipo and cyclo oxygenases
• Synopsis of arachidonic acid metabolism
• Arachidonic acid metabolism
• Is arachidonic acid
• Arachidonic acid an endoschistosomicide
• Rat schistosomiasis
• Oil Red O staining
• Specific anti ARA antibody based
• Polyunsaturated fatty acids
• Sulfur amino acid
• Hydrogen sulfide
• Nitric oxide
• Metabolic engineering
• Potential source
• Plants as potential source
• BMC Biotechnology
• Mortierella Alpina
• Dissolved oxygen
• Heavy ion mutagenesis
• Octyl gallate
• Molecular breeding
• Fatty acid desaturase
• Mortierella alpina 1S 4
• Unsaturated fatty acids
• Free radicals
• Metabolites function
• Endogenous antimicrobial molecules
• Ion channels
• Physiological roles
• Potential health benefits
• Membranes undergoes reacylation cycles
• BMC Cancer
• Cancer remains
• Prostaglandin E2
• Methodological limitations
• Type 2 cytokines
• Schistosomiasis vaccine
• Metabolic syndrome
• Pathogenic potential of uric acid
• BMC Geriatrics
• Lifestyle habits
• Long chain polyunsaturated fatty acids
• Cognitive leisure activities
• Maintaining cognitive function
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• báo cáo hóa học
• công trình nghiên cứu về hóa học
• tài liệu về hóa học
• cách trình bày báo cáo
• Report medicine
• traditional medicine
• scientific reports
• medical knowledge
• medical research
• analysis of cytoplasmic
• Structural biochemistry
• oxidation
• bacteria
• chemical reaction
• Leptinotarsa decemlineata
• Treating fungus injected
• Eicosanoid biosynthesis
• B
• bassiana
• L
• decmlineata
• Schistosoma mansoni
• Antibody response
• Uric and arachidonic acid
• Papain enzymatic activity
• The protection induced
• Cysteine protease against
• Schistosoma haematobium
• Excretory–secretory products
• Type 2 adjuvants
• BMC Chemistry
• Dibenzylidene ketone derivatives
• Computational studies
• Human capsaicin receptor
• Journal of Chemistry
• Nitro compounds
• N carbamothioyl
• Soybean 15 LOX
• Nitrophenoxy chromenone derivative
• Arachidonic acid (AA)
• BMC Pediatrics
• Human milk provides
• Infant nutrition
• Multifunctional iron binding protein
• Adjusted arachidonic acid
• BMC Plant Biology
• Diacylglycerol acyltransferase
• Lipid droplet
• Lobosphaera incisa
• Genome Biology
• Ovarian carcinoma
• Tumor associated macrophages
• Tumor microenvironment
• Malignancy associated ascites
• Signaling network