TAILIEUCHUNG - Arachidonic acid production by the oleaginous fungus Mortierella alpina 1S-4: A review

The filamentous fungus Mortierella alpina 1S-4 is capable of accumulating a large amount of triacylglycerol containing C20 polyunsaturated fatty acids (PUFAs). Indeed, triacylglycerol production by M. alpina 1S-4 can reach 20 g/L of culture broth, and the critical cellular signaling and structural PUFA arachidonic acid (ARA) comprises 30%–70% of the total fatty acid. The demonstrated health benefits of functional PUFAs have in turn encouraged the search for rich sources of these compounds, including fungal strains showing enhanced production of specific PUFAs. Screening for mutants and targeted gene manipulation of M. alpina 1S-4 have elucidated the functions of various enzymes involved in PUFA biosynthesis and established lines with improved PUFA productivity. In some cases, these strains have been used for indistrial-scale production of PUFAs, including ARA. In this review, we described practical ARA production through mutant breeding, functional analyses of genes encoding enzymes involved in PUFA biosynthesis, and recent advances in the production of specific PUFAs through molecular breeding of M. alpina 1S-4 | Arachidonic acid production by the oleaginous fungus Mortierella alpina 1S-4: A review

• Sinh học
• Arachidonic acid
• Mortierella alpina
• Molecular breeding
• Fatty acid desaturase
• Mortierella alpina 1S 4
• Delta desaturases
• Lipo and cyclo oxygenases
• Synopsis of arachidonic acid metabolism
• Arachidonic acid metabolism
• Is arachidonic acid
• Arachidonic acid an endoschistosomicide
• Rat schistosomiasis
• Oil Red O staining
• Specific anti ARA antibody based
• Polyunsaturated fatty acids
• Sulfur amino acid
• Hydrogen sulfide
• Nitric oxide
• Metabolic engineering
• Potential source
• Plants as potential source
• BMC Biotechnology
• Dissolved oxygen
• Heavy ion mutagenesis
• Octyl gallate
• Unsaturated fatty acids
• Free radicals
• Metabolites function
• Endogenous antimicrobial molecules
• Lipoxin A4
• Pre eclampsia
• Diabetes mellitus
• Hypertension and diabetes mellitus
• Ion channels
• Physiological roles
• Potential health benefits
• Membranes undergoes reacylation cycles
• BMC Cancer
• Cancer remains
• Prostaglandin E2
• Methodological limitations
• Type 2 cytokines
• Schistosomiasis vaccine
• Metabolic syndrome
• Pathogenic potential of uric acid
• BMC Geriatrics
• Lifestyle habits
• Long chain polyunsaturated fatty acids
• Cognitive leisure activities
• Maintaining cognitive function
• báo cáo khoa học
• báo cáo hóa học
• công trình nghiên cứu về hóa học
• tài liệu về hóa học
• cách trình bày báo cáo
• Report medicine
• traditional medicine
• scientific reports
• medical knowledge
• medical research
• analysis of cytoplasmic
• Structural biochemistry
• oxidation
• bacteria
• chemical reaction
• Leptinotarsa decemlineata
• Treating fungus injected
• Eicosanoid biosynthesis
• B
• bassiana
• L
• decmlineata
• Schistosoma mansoni
• Antibody response
• Uric and arachidonic acid
• Papain enzymatic activity
• The protection induced
• Cysteine protease against
• Schistosoma haematobium
• Excretory–secretory products
• Type 2 adjuvants
• BMC Chemistry
• Dibenzylidene ketone derivatives
• Computational studies
• Human capsaicin receptor
• Journal of Chemistry
• Nitro compounds
• N carbamothioyl
• Soybean 15 LOX
• Nitrophenoxy chromenone derivative
• Arachidonic acid (AA)
• BMC Pediatrics
• Human milk provides
• Infant nutrition
• Multifunctional iron binding protein
• Adjusted arachidonic acid
• BMC Plant Biology
• Diacylglycerol acyltransferase
• Lipid droplet
• Lobosphaera incisa
• Genome Biology
• Ovarian carcinoma
• Tumor associated macrophages
• Tumor microenvironment
• Malignancy associated ascites
• Signaling network