TAILIEUCHUNG - Ageing: Is there a role for arachidonic acid and other bioactive lipids? A review

Ageing is inevitable. Recent studies suggest that it could be delayed. Low-grade systemic inflammation is seen in type 2 diabetes mellitus, hypertension and endothelial dysfunction that are common with increasing age. In all these conditions, an alteration in arachidonic acid (AA) metabolism is seen in the form of increased formation of pro-inflammatory eicosanoids and decreased production of anti-inflammatory lipoxins, resolvins, protectins and maresins and decreased activity of desaturases. Calorie restriction, exercise and parabiosis delay age-related changes that could be related to enhanced proliferation of stem cells, decrease in inflammation and transfer of GDF-11 (growth differentiation factor-11) and other related molecules from the young to the old, increase in the formation of lipoxin A4, resolvins, protectins and maresins, hydrogen sulfide (H2S) and nitric oxide (NO); inhibition of ageing-related hypothalamic or brain IKK-b and NF-kB activation, decreased gonadotropin-releasing hormone (GnRH) release resulting in increased neurogenesis and consequent decelerated ageing. This suggests that hypothalamus participates in ageing process. N-acylethanolamines (NAEs) and lipid-derived signalling molecules can be tuned favorably under dietary restriction to extend lifespan and/or prevent advanced age associated diseases in an mTOR dependent pathwaymanner. | Ageing: Is there a role for arachidonic acid and other bioactive lipids? A review

• Sinh học
• Arachidonic acid
• Polyunsaturated fatty acids
• Sulfur amino acid
• Hydrogen sulfide
• Nitric oxide
• Delta desaturases
• Lipo and cyclo oxygenases
• Synopsis of arachidonic acid metabolism
• Arachidonic acid metabolism
• Is arachidonic acid
• Arachidonic acid an endoschistosomicide
• Rat schistosomiasis
• Oil Red O staining
• Specific anti ARA antibody based
• Metabolic engineering
• Potential source
• Plants as potential source
• BMC Biotechnology
• Mortierella Alpina
• Dissolved oxygen
• Heavy ion mutagenesis
• Octyl gallate
• Molecular breeding
• Fatty acid desaturase
• Mortierella alpina 1S 4
• Unsaturated fatty acids
• Free radicals
• Metabolites function
• Endogenous antimicrobial molecules
• Lipoxin A4
• Pre eclampsia
• Diabetes mellitus
• Hypertension and diabetes mellitus
• Ion channels
• Physiological roles
• Potential health benefits
• Membranes undergoes reacylation cycles
• BMC Cancer
• Cancer remains
• Prostaglandin E2
• Methodological limitations
• Type 2 cytokines
• Schistosomiasis vaccine
• Metabolic syndrome
• Pathogenic potential of uric acid
• BMC Geriatrics
• Lifestyle habits
• Long chain polyunsaturated fatty acids
• Cognitive leisure activities
• Maintaining cognitive function
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• Report medicine
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• scientific reports
• medical knowledge
• medical research
• analysis of cytoplasmic
• Structural biochemistry
• oxidation
• bacteria
• chemical reaction
• Leptinotarsa decemlineata
• Treating fungus injected
• Eicosanoid biosynthesis
• B
• bassiana
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• decmlineata
• Schistosoma mansoni
• Antibody response
• Uric and arachidonic acid
• Papain enzymatic activity
• The protection induced
• Cysteine protease against
• Schistosoma haematobium
• Excretory–secretory products
• Type 2 adjuvants
• BMC Chemistry
• Dibenzylidene ketone derivatives
• Computational studies
• Human capsaicin receptor
• Journal of Chemistry
• Nitro compounds
• N carbamothioyl
• Soybean 15 LOX
• Nitrophenoxy chromenone derivative
• Arachidonic acid (AA)
• BMC Pediatrics
• Human milk provides
• Infant nutrition
• Multifunctional iron binding protein
• Adjusted arachidonic acid
• BMC Plant Biology
• Diacylglycerol acyltransferase
• Lipid droplet
• Lobosphaera incisa
• Genome Biology
• Ovarian carcinoma
• Tumor associated macrophages
• Tumor microenvironment
• Malignancy associated ascites
• Signaling network